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FLASH GENE
Symbol CD276 contributors: mct - updated : 04-05-2016
HGNC name CD276 antigen
HGNC id 19137
DNA
TYPE functioning gene
STRUCTURE 30.24 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - 341 - 2002 12055244
  • 8 exons resulting of duplication of two exons
  • four IG-like domains
  • 10 - 3419 - 534 - 2002 12055244
    8 - 2765 - 316 - 2002 12055244
  • B7-H3a
  • lacking exon 4 and 5
  • - - - - - - 2008 18690846
  • tumor-associated antigen with potential role in tumor progression and metastasis
  • could be detected in the whole process of maturation of dendritic cells
  • major isoform on many human tumor cell lines
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Reproductivefemale systembreastmammary gland  
     female systemuterus   
     male systemtestis   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, neonatal, pregnancy
    Text expression increases during the last half of pregnancy, and is maximal during lactation, developing bone
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal signal peptide
  • extracellular V- and C-like Ig domains with 4 conserved cysteine residues
  • a transmembrane region
  • a 45-amino acid cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine B7h3
    Homologene
    FAMILY
  • immunoglobulin superfamily, B7 immunoregulatory family
  • BTN/MOG family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be acting as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane
  • playing a regulatory role in bone formation
  • negative regulator that preferentially affects T cell mediated immune responses
  • function as a regulator of antitumor immunity
  • HLA-G, CD274 and CD276, are secreted from early and term placenta, and have important implications in the mechanisms by which trophoblast immunomodulators modify the maternal immunological environment
  • plays an important role in adaptive immune responses, and may have a novel role in regulating pancreatic tumor progression
  • may have a critical role in primary hepatocellular carcinoma and it may enhance tumor escape from the immune surveillance of CD8(+) T cells
  • might play an important role in angiogenesis of Renal cell carcinoma (RCC) mediated by CD14(+) monocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia
    tumoral     --over  
    in oral squamous cell carcinoma (OSCC), and its overexpression correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients
    tumoral     --over  
    in the pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    CD276 silencing inhibits tumor progression of mantle cell lymphoma and enhances chemosensitivity
    cancerlung 
    is a promising target for new immunotherapeutic strategies in MM, with particular emphasis in the epithelial variant (malignant mesothelioma (MM)
    ANIMAL & CELL MODELS