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FLASH GENE

Symbol

VKORC1

contributors: mct - updated : 07-04-2014

HGNC name	vitamin K epoxide reductase complex, subunit 1
HGNC id	23663

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	homozygous Vkorc1-deficient mice developed normally until birth, but within 2-20 days after birth, the knockout mice died due to extensive, predominantly intracerebral haemorrhage
	homozygous Vkorc1-/- mice die in 2–20 days after birth by extensive bleeding due to a total deficiency of the gamma-carboxylation of the clotting factors in liver