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FLASH GENE
Symbol VKORC1 contributors: mct - updated : 07-04-2014
HGNC name vitamin K epoxide reductase complex, subunit 1
HGNC id 23663
ANIMAL & CELL MODELS
  • homozygous Vkorc1-deficient mice developed normally until birth, but within 2-20 days after birth, the knockout mice died due to extensive, predominantly intracerebral haemorrhage
  • homozygous Vkorc1-/- mice die in 220 days after birth by extensive bleeding due to a total deficiency of the gamma-carboxylation of the clotting factors in liver