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FLASH GENE

Symbol

PDYN

contributors: mct - updated : 30-03-2017

HGNC name	prodynorphin
HGNC id	8820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCA23

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   occurring during aging and AD may mediate cognitive deficits by altering the glutamatergic system integrity constitutional     --low   in frontotemporal dementia (FTD)

Susceptibility

to alcohol dependence to opioid addiction to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition

Variant & Polymorphism repeat , other	allelic variation at the promoter contributing to prtection against cocaine dependence
	polymorphisms increasing alcohol dependence
	functional allelic variants in the PDYN promoter might modify the risk to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
	polymorphisms in PDYN are associated with opioid addiction

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention

ANIMAL & CELL MODELS