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FLASH GENE

Symbol

PDYN

contributors: mct - updated : 30-03-2017

HGNC name	prodynorphin
HGNC id	8820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N terminal six conserved cysteines

HOMOLOGY

interspecies

homolog to murine Pdyn

Homologene

FAMILY

opioids neuropeptides precursors family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	translocation across the plasma membrane may represent a previously unknown mechanism by which dynorphins can signal information to the cell interior

basic FUNCTION	playing a role in Alzheimer disease neuropathology
	induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors
	essential role of dynorphin in the termination of seizures
	activates bradykinin receptors to maintain neuropathic pain
	regulate pain processing and modulate the rewarding effects of addictive substances
	acts as a neuromodulator to inhibit ITCH in the dorsal horn of the spinal cord

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between OPRK1 and its native peptide ligand PDYN
	REST represses PDYN expression in neuroblastoma cells and the adult human brain and may have implications for mental health and brain/mental disorders

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCA23

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   occurring during aging and AD may mediate cognitive deficits by altering the glutamatergic system integrity constitutional     --low   in frontotemporal dementia (FTD)

Susceptibility

to alcohol dependence to opioid addiction to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition

Variant & Polymorphism repeat , other	allelic variation at the promoter contributing to prtection against cocaine dependence
	polymorphisms increasing alcohol dependence
	functional allelic variants in the PDYN promoter might modify the risk to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
	polymorphisms in PDYN are associated with opioid addiction

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention

ANIMAL & CELL MODELS