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FLASH GENE
Symbol PDGFB contributors: mct/ - updated : 05-11-2017
HGNC name platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
HGNC id 8800
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Pdgfb (87.97 pc)
homolog to murine Pdgfb (89.63 pc)
Homologene
FAMILY
  • PDGF/VEGF growth factor family
    • CATEGORY protooncogene , signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • potent mitogen for cells of mesenchymal origin, also involved in transformation process
  • potent negative regulator of smooth muscle cell (SMC) differentiation
  • might be involved in the activation of primordial follicles
  • growth factor involved in the recruitment and function of pericytes
  • PDGFB signaling in trophoblasts is a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem/progenitor cell (HSPC) from premature differentiation
  • induces senescence and transformation in normal human fibroblasts, but has a limited ability to induce senescence
  • mitogen for hepatic stellate cells (HSC)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
  • homodimerizing or heterodimerizing with PDGFA,(PDGFBB or PDGFAB)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRA, PDGFRB
  • XLKD1
  • PDGFB may regulate THBD expression in VSMCs during vascular remodelling
  • SERPINA12 significantly inhibited PDGFB-induced smooth muscle cells (SMCs) migration
  • PDGFB-induced activation of MAPK14 was significantly suppressed by SERPINA12
  • SF1 antagonizes PDGFB-induced growth and dedifferentiation of vascular smooth muscle cells
  • LAMTOR5 upregulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells
  • angiogenesis is stimulated by KLK12 acting via a PDGFB-dependent paracrine pathway
  • LHX2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGFB signaling
  • NOTCH2 inhibits PDGFB-dependent proliferation and its expression is decreased by PDGFB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFSP , BGCI5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation --other protein chimeric
    translocation t(17;22) (q22;q13) with chimeric proteins 5' - COL1A1 - PDGFB - 3' in meningiomas, in dermatofibrosarcoma protuberans
    constitutional     --low  
    in human venous malformations (VM) lesions
    constitutional       loss of function
    increases hepatic vascular permeability and enhances insulin sensitivity
    tumoral     --over  
    with LAMTOR5 were highly expressed in breast cancer cell lines
    Susceptibility
  • meningiomas
  • dermatofibrosarcoma protuberans
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    anti-platelet therapy or selective inhibition of PDGFB might reduce biliary fibrosis in patients with liver disease
    ANIMAL & CELL MODELS
  • transgenic mice in which Pdgf-B was over-expressed, exhibited enhanced apoptosis in the developing corpus striatum, and in retinal progenitors results in abnormal retinal vessel formation