SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
|
| intracellular
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| intracellular,cytoplasm,organelle,lumen
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
basic FUNCTION
| potent mitogen for cells of mesenchymal origin, also involved in transformation process |
|
potent negative regulator of smooth muscle cell (SMC) differentiation |
|
might be involved in the activation of primordial follicles |
|
growth factor involved in the recruitment and function of pericytes |
|
PDGFB signaling in trophoblasts is a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem/progenitor cell (HSPC) from premature differentiation |
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induces senescence and transformation in normal human fibroblasts, but has a limited ability to induce senescence |
|
mitogen for hepatic stellate cells (HSC) |