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FLASH GENE
Symbol PDGFB contributors: mct/ - updated : 05-11-2017
HGNC name platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
HGNC id 8800
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
 vessel   highly
Digestiveintestinelarge intestinecolon lowly
 mouth   highly
Nervousbrain   moderately
Reproductivefemale systemplacenta  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Reproductivegranulosa cell Homo sapiens
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Pdgfb (87.97 pc)
homolog to murine Pdgfb (89.63 pc)
Homologene
FAMILY
  • PDGF/VEGF growth factor family
    • CATEGORY protooncogene , signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • potent mitogen for cells of mesenchymal origin, also involved in transformation process
  • potent negative regulator of smooth muscle cell (SMC) differentiation
  • might be involved in the activation of primordial follicles
  • growth factor involved in the recruitment and function of pericytes
  • PDGFB signaling in trophoblasts is a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem/progenitor cell (HSPC) from premature differentiation
  • induces senescence and transformation in normal human fibroblasts, but has a limited ability to induce senescence
  • mitogen for hepatic stellate cells (HSC)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
  • homodimerizing or heterodimerizing with PDGFA,(PDGFBB or PDGFAB)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRA, PDGFRB
  • XLKD1
  • PDGFB may regulate THBD expression in VSMCs during vascular remodelling
  • SERPINA12 significantly inhibited PDGFB-induced smooth muscle cells (SMCs) migration
  • PDGFB-induced activation of MAPK14 was significantly suppressed by SERPINA12
  • SF1 antagonizes PDGFB-induced growth and dedifferentiation of vascular smooth muscle cells
  • LAMTOR5 upregulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells
  • angiogenesis is stimulated by KLK12 acting via a PDGFB-dependent paracrine pathway
  • LHX2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGFB signaling
  • NOTCH2 inhibits PDGFB-dependent proliferation and its expression is decreased by PDGFB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFSP , BGCI5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation --other protein chimeric
    translocation t(17;22) (q22;q13) with chimeric proteins 5' - COL1A1 - PDGFB - 3' in meningiomas, in dermatofibrosarcoma protuberans
    constitutional     --low  
    in human venous malformations (VM) lesions
    constitutional       loss of function
    increases hepatic vascular permeability and enhances insulin sensitivity
    tumoral     --over  
    with LAMTOR5 were highly expressed in breast cancer cell lines
    Susceptibility
  • meningiomas
  • dermatofibrosarcoma protuberans
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    anti-platelet therapy or selective inhibition of PDGFB might reduce biliary fibrosis in patients with liver disease
    ANIMAL & CELL MODELS
  • transgenic mice in which Pdgf-B was over-expressed, exhibited enhanced apoptosis in the developing corpus striatum, and in retinal progenitors results in abnormal retinal vessel formation