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FLASH GENE

Symbol

TARDBP

contributors: shn/mct - updated : 12-01-2022

HGNC name	TAR DNA binding protein
HGNC id	11571

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	postnatal deletion of Tardbp in mice caused dramatic loss of body fat followed by rapid death
	aberrant Tdp-43- and FUS/TLS-positive nuclear inclusions, abnormal accumulation of mitochondria in motor neurons, immature neuromuscular junctions, and atrophy of skeletal muscle in Tdp-43 mice
	In SH-SY5Y human neuroblastoma cells, knockdown of TDP-43 caused altered splicing of about 200 transcripts (
	autophagy activation is an effective route for therapy of Tdp-43 Tg mice with FTLD-U phenotypes