| 1 | STMN2, TARDBP
|
| Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy.
|
| Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A.
|
| Cell Rep. Jun 28;39(13):111001. doi: 10.1016/j.celrep.2022.111001. 2022
|
| 2 | TARDBP
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| Characterization of the human TARDBP gene promoter
|
| Baralle M, Romano M.
|
| Sci Rep. May 17;11(1):10438. doi: 10.1038/s41598-021-89973-z. 2021
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| 3 | TARDBP
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| TDP-43 Pathology in Alzheimer's Disease
|
| Meneses A, Koga S, O'Leary J, Dickson DW, Bu G, Zhao N.
|
| Mol Neurodegener. Dec 20;16(1):84. doi: 10.1186/s13024-021-00503-x. 2021
|
| 4 | STMN2, TARDBP
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| Connecting TDP-43 Pathology with Neuropathy.
|
| Klim JR, Pintacuda G, Nash LA, Guerra San Juan I, Eggan K.
|
| Trends Neurosci. Jun;44(6):424-440. doi: 10.1016/j.tins.2021.02.008. Epub 2021 Apr 5. 2021
|
| 5 | PSMG2, TARDBP
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| Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system.
|
| Yin P, Bai D, Zhu L, Deng F, Guo X, Li B, Chen L, Li S, Li XJ.
|
| Exp Neurol. Nov;345:113833. doi: 10.1016/j.expneurol.2021.113833. Epub 2021 Aug 5. 2021
|
| 6 | PTK2, TARDBP
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| PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies
|
| Lee S, Jeon YM, Cha SJ, Kim S, Kwon Y, Jo M, Jang YN, Lee S, Kim J, Kim SR, Lee KJ, Lee SB, Kim K, Kim HJ.
|
| Autophagy. Aug;16(8):1396-1412. doi: 10.1080/15548627.2019.1686729. Epub 2019 Nov 5. 2020
|
| 7 | TARDBP
|
| The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
|
| Jo M, Lee S, Jeon YM, Kim S, Kwon Y, Kim HJ.
|
| Exp Mol Med. Oct;52(10):1652-1662. doi: 10.1038/s12276-020-00513-7. Epub 2020 Oct 13. 2020
|
| 8 | TARDBP
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| Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
|
| Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus JM, Shi J, Heckman MG, Spiegel MR, Cook C, Song Y, Yue M, Daughrity LM, Carlomagno Y, Jansen-West K, de Castro CF, DeTure M, Koga S, Wang YC, Sivakumar P, Bodo C, Candalija A, Talbot K, Selvaraj BT, Burr K, Chandran S, Newcombe J, Lashley T, Hubbard I, Catalano D, Kim D, Propp N, Fennessey S; NYGC ALS Consortium, Fagegaltier D, Phatnani H, Secrier M, Fisher EM, Oskarsson B, van Blitterswijk M, Rademakers R, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Josephs KA, Thompson EA, Raj T, Ward M, Dickson DW, Gendron TF, Fratta P, Petrucelli L.
|
| J Clin Invest. Nov 2;130(11):6080-6092. doi: 10.1172/JCI139741. 2020
|
| 9 | ALS10, TARDBP
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| Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
|
| Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK.
|
| Front Mol Neurosci. Feb 14;12:25. doi: 10.3389/fnmol.2019.00025. 2019
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| 10 | STMN2, TARDBP
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| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
|
| Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW.
|
| Nat Neurosci. Feb;22(2):180-190. doi: 10.1038/s41593-018-0293-z. Epub 2019 Jan 14. 2019
|
| 11 | ATG4B, TARDBP
|
| Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue.
|
| Torres P, Ramírez-Núńez O, Romero-Guevara R, Barés G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchís D, Pamplona R, Ferrer I, Portero-Otín M.
|
| Autophagy ;14(8):1398-1403. doi: 10.1080/15548627.2018.1474311. Epub 2018 Jul 28. 2018
|
| 12 | FMR1, TARDBP
|
| Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP.
|
| Majumder P, Chu JF, Chatterjee B, Swamy KB, Shen CJ.
|
| Acta Neuropathol 132(5):721-738. Epub 2016 Aug 12.
2016
|
| 13 | TARDBP
|
| The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
|
| Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X.
|
| Nat Med. Aug;22(8):869-78. doi: 10.1038/nm.4130. Epub 2016 Jun 27. 2016
|
| 14 | TARDBP
|
| Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43
|
| Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, Koyama M, Konno T, Hirokawa S, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O.
|
| Nucleic Acids Res. Jul 8;44(12):5820-36. doi: 10.1093/nar/gkw499. Epub 2016 Jun 2. 2016
|
| 15 | ALS10, TARDBP, TTBK1, TTBK2
|
| The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
|
| Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, Leverenz JB, Kraemer BC.
|
| PLoS Genet LoS Genet. 2014 2014
|
| 16 | GSK3B, RMDN3, TARDBP
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| ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
|
| Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC.
|
| Nat Commun. Jun 3;5:3996. doi: 10.1038/ncomms4996 2014
|
| 17 | TARDBP
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| Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.
|
| Ishihara T, Ariizumi Y, Shiga A, Kato T, Tan CF, Sato T, Miki Y, Yokoo M, Fujino T, Koyama A, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O.
|
| Hum Mol Genet 22(20):4136-47. doi: 10.1093/hmg/ddt262. Epub 2013 Jun 4.
2013
|
| 18 | HDAC6, PRKN, TARDBP
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| Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
|
| Hebron ML, Lonskaya I, Sharpe K, Weerasinghe PP, Algarzae NK, Shekoyan AR, Moussa CE.
|
| J Biol Chem 288(6):4103-15. doi: 10.1074/jbc.M112.419945. Epub 2012 Dec 20. 2013
|
| 19 | TARDBP
|
| Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion
|
| Jiang LL, Che MX, Zhao J, Zhou CJ, Xie MY, Li HY, He JH, Hu HY.
|
| J Biol Chem. Jul 5;288(27):19614-24. doi: 10.1074/jbc.M113.463828. Epub 2013 May 20. 2013
|
| 20 | TARDBP
|
| TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
|
| Higashi S, Kabuta T, Nagai Y, Tsuchiya Y, Akiyama H, Wada K.
|
| J Neurochem. Jul;126(2):288-300. doi: 10.1111/jnc.12194. Epub 2013 Mar 1 2013
|
| 21 | FMR1, STAU1, TARDBP
|
| Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.
|
| Yu Z, Fan D, Gui B, Shi L, Xuan C, Shan L, Wang Q, Shang Y, Wang Y.
|
| J Biol Chem 287(27):22560-72. Epub 2012 May 14.
2012
|
| 22 | TARDBP
|
| TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
|
| Kawahara Y, Mieda-Sato A.
|
| Proc Natl Acad Sci U S A. 109(9):3347-52. 2012
|
| 23 | TARDBP
|
| Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism.
|
| Keller BA, Volkening K, Droppelmann CA, Ang LC, Rademakers R, Strong MJ.
|
| Acta Neuropathol. 124(5):733-47 2012
|
| 24 | TARDBP
|
| Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis.
|
| Scofield MD, Korutla L, Jackson TG, Kalivas PW, Mackler SA.
|
| Neuroscience. 227:44-54. 2012
|
| 25 | TARDBP
|
| p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions.
|
| Tanji K, Zhang HX, Mori F, Kakita A, Takahashi H, Wakabayashi K.
|
| J Neurosci Res. 90(10):2034-42 2012
|
| 26 | LGMN, TARDBP
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| Asparaginyl endopeptidase cleaves TDP-43 in brain.
|
| Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT.
|
| Proteomics 12(15-16):2455-63. doi: 10.1002/pmic.201200006.
2012
|
| 27 | EGR2, TARDBP
|
| Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
|
| Postel-Vinay S, Véron AS, Tirode F, Pierron G, Reynaud S, Kovar H, Oberlin O, Lapouble E, Ballet S, Lucchesi C, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, de Paillerets BB, Laud K, Dina C, Froguel P, Clavel-Chapelon F, Doz F, Michon J, Chanock SJ, Thomas G, Cox DG, Delattre O.
|
| Nat Genet 44(3):323-7. doi: 10.1038/ng.1085.
2012
|
| 28 | CDC37, MAPT, TARDBP
|
| Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
|
| Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA.
|
| J Biol Chem 287(29):24814-20. doi: 10.1074/jbc.M112.367268. Epub 2012 Jun 6.
2012
|
| 29 | ALS10, TARDBP
|
| The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.
|
| Fallini C, Bassell GJ, Rossoll W.
|
| Hum Mol Genet 21(16):3703-18. doi: 10.1093/hmg/dds205. Epub 2012 May 28.
2012
|
| 30 | TARDBP
|
| The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity.
|
| Chang CK, Wu TH, Wu CY, Chiang MH, Toh EK, Hsu YC, Lin KF, Liao YH, Huang TH, Huang JJ.
|
| Biochem Biophys Res Commun 425(2):219-24. doi: 10.1016/j.bbrc.2012.07.071. Epub 2012 Jul 23.
2012
|
| 31 | DBR1, TARDBP
|
| TDP-43 toxicity and the usefulness of junk.
|
| Sun S, Cleveland DW.
|
| Nat Genet 44(12):1289-91. doi: 10.1038/ng.2473.
2012
|
| 32 | DBR1, TARDBP
|
| Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
|
| Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV Jr, Gitler AD.
|
| Nat Genet 44(12):1302-9. doi: 10.1038/ng.2434. Epub 2012 Oct 28.
2012
|
| 33 | TARDBP
|
| Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
|
| Wang IF, Guo BS, Liu YC, Wu CC, Yang CH, Tsai KJ, Shen CK.
|
| Proc Natl Acad Sci U S A 109(37):15024-9. doi: 10.1073/pnas.1206362109.
2012
|
| 34 | FMR1, STAU1, TARDBP
|
| Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.
|
| Yu Z, Fan D, Gui B, Shi L, Xuan C, Shan L, Wang Q, Shang Y, Wang Y.
|
| J Biol Chem 287(27):22560-72. doi: 10.1074/jbc.M112.357582. Epub 2012 May 14.
2012
|
| 35 | TARDBP
|
| TDP-43 regulates its mRNA levels through a negative feedback loop.
|
| Ayala YM, De Conti L, Avendańo-Vázquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E, Baralle FE.
|
| EMBO J 30(2):277-88. Epub 2010 Dec 3.
2011
|
| 36 | TARDBP
|
| Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
|
| Brady OA, Meng P, Zheng Y, Mao Y, Hu F.
|
| J Neurochem 116(2):248-59. doi: 10.1111/j.1471-4159.2010.07098.x. Epub 2010 Dec 2.
2011
|
| 37 | TARDBP
|
| TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
|
| Dewey CM, Cenik B, Sephton CF, Dries DR, Mayer P 3rd, Good SK, Johnson BA, Herz J, Yu G.
|
| Mol Cell Biol 31(5):1098-108. Epub 2010 Dec 20.
2011
|
| 38 | TARDBP
|
| TDP-43: multiple targets, multiple disease mechanisms?
|
| Sendtner M.
|
| Nat Neurosci. 14(4):403-5. 2011
|
| 39 | BCL2L1, BCL2L11, TARDBP
|
| TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
|
| Suzuki H, Lee K, Matsuoka M.
|
| J Biol Chem 286(15):13171-83. Epub 2011 Feb 21.
2011
|
| 40 | TARDBP
|
| TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling.
|
| Zhang T, Mullane PC, Periz G, Wang J.
|
| Hum Mol Genet 20(10):1952-65. Epub 2011 Feb 25.
2011
|
| 41 | MAP1B, TARDBP
|
| TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.
|
| Godena VK, Romano G, Romano M, Appocher C, Klima R, Buratti E, Baralle FE, Feiguin F.
|
| PLoS One 6(3):e17808. doi: 10.1371/journal.pone.0017808.
2011
|
| 42 | TARDBP
|
| TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies.
|
| Cohen TJ, Lee VM, Trojanowski JQ.
|
| Trends Mol Med. 17(11):659-67. 2011
|
| 43 | TARDBP
|
| Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
|
| Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N.
|
| J Biol Chem 285(1):608-19. Epub 2009 Nov 3.PMID: 19887443 2010
|
| 44 | TARDBP
|
| TDP-43 is a developmentally regulated protein essential for early embryonic development.
|
| Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P 3rd, Herz J, Yu G.
|
| J Biol Chem 285(9):6826-34. Epub 2009 Dec 29.PMID: 20040602 2010
|
| 45 | ALS10, TARDBP
|
| Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
|
| Kabashi E, Lin L, Tradewell ML, Dion PA, Bercier V, Bourgouin P, Rochefort D, Bel Hadj S, Durham HD, Vande Velde C, Rouleau GA, Drapeau P.
|
| Hum Mol Genet 19(4):671-83. Epub 2009 Dec 3.PMID: 19959528 2010
|
| 46 | FUS, TARDBP
|
| TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.
|
| Lagier-Tourenne C, Polymenidou M, Cleveland DW.
|
| Hum Mol Genet 19(R1):R46-64. Epub 2010 Apr 15. Review.PMID: 20400460 2010
|
| 47 | ALS10, ALS6, FUS, TARDBP
|
| ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
|
| Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.
|
| Proc Natl Acad Sci U S A 107(30):13318-23. Epub 2010 Jul 12.PMID: 20624952 2010
|
| 48 | ALS1, ALS10, ALS6, ALS8, ALS9, ANG, FUS, SOD1, TARDBP, VAPB
|
| SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
|
| Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V.
|
| J Med Genet 47(8):554-60. Epub 2010 Jun 24.PMID: 20577002 2010
|
| 49 | ALS10, ATXN2, TARDBP
|
| Neurodegeneration: An expansion in ALS genetics.
|
| Lagier-Tourenne C, Cleveland DW.
|
| Nature 466(7310):1052-3. No abstract available. 2010
|
| 50 | ATXN2, TARDBP
|
| Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
|
| Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD.
|
| Nature 466(7310):1069-75. 2010
|
| 51 | TARDBP, TBC1D1
|
| Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
|
| Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC.
|
| Proc Natl Acad Sci U S A 107(37):16320-4. Epub 2010 Jul 26.PMID: 20660762 2010
|
| 52 | TARDBP
|
| Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
|
| Shan X, Chiang PM, Price DL, Wong PC.
|
| Proc Natl Acad Sci U S A 107(37):16325-30. Epub 2010 Aug 24.PMID: 20736350 2010
|
| 53 | FUS, HDAC6, TARDBP
|
| Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
|
| Kim SH, Shanware NP, Bowler MJ, Tibbetts RS.
|
| J Biol Chem 285(44):34097-105. Epub 2010 Aug 18.
2010
|
| 54 | TARDBP
|
| Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.
|
| Fiesel FC, Voigt A, Weber SS, Van den Haute C, Waldenmaier A, Görner K, Walter M, Anderson ML, Kern JV, Rasse TM, Schmidt T, Springer W, Kirchner R, Bonin M, Neumann M, Baekelandt V, Alunni-Fabbroni M, Schulz JB, Kahle PJ.
|
| EMBO J. 29(1):209-21. 2010
|
| 55 | ALS6, FUS, TARDBP
|
| Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
|
| Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
|
| Science 323(5918):1205-8. 2009
|
| 56 | ALS6, FUS, TARDBP
|
| Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
|
| Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE.
|
| Science 323(5918):1208-11. 2009
|
| 57 | ALS6, FUS, TARDBP
|
| Rethinking ALS: the FUS about TDP-43.
|
| Lagier-Tourenne C, Cleveland DW.
|
| Cell 136(6):1001-4. Review. 2009
|
| 58 | TARDBP
|
| Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
|
| Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L.
|
| Proc Natl Acad Sci U S A 106(18):7607-12. Epub 2009 Apr 21.
2009
|
| 59 | ALS10, TARDBP
|
| Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis.
|
| Daoud H, Valdmanis PN, Kabashi E, Dion P, Dupré N, Camu W, Meininger V, Rouleau GA.
|
| J Med Genet 46(2):112-4. Epub 2008 Oct 17.
2009
|
| 60 | TARDBP
|
| TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
|
| Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G.
|
| J Biol Chem 284(33):22059-66. Epub 2009 Jun 17.PMID: 19535326 2009
|
| 61 | ALS10, FTLD, TARDBP
|
| Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
|
| Pesiridis GS, Lee VM, Trojanowski JQ.
|
| Hum Mol Genet 18(R2):R156-62. Review.PMID: 19808791 2009
|
| 62 | TARDBP
|
| Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
|
| Kim SH, Shi Y, Hanson KA, Williams LM, Sakasai R, Bowler MJ, Tibbetts RS.
|
| J Biol Chem. 284(12):8083-92. 2009
|
| 63 | GRN, FTDU17, TARDBP
|
| Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
|
| Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C.
|
| J Biol Chem 283(3):1744-53. Epub 2007 Nov 5. 2008
|
| 64 | TARDBP, ALS10
|
| TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
|
| Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD, Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE.
|
| Science 319(5870):1668-72. Epub 2008 Feb 28. 2008
|
| 65 | TARDBP, CDK6
|
| TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression.
|
| Ayala YM, Misteli T, Baralle FE.
|
| Proc Natl Acad Sci U S A 105(10):3785-9. Epub 2008 Feb 27. 2008
|
| 66 | TARDBP, GRN
|
| Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
|
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| Nat Genet 40(5):572-4. Epub 2008 Mar 30. 2008
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| 74 | FTLD, TARDBP, VCP
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| J Neuropathol Exp Neurol 66(2):152-7.
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| 75 | NEFL, TARDBP
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| TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein.
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| 76 | TARDBP, GRN
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| 79 | ANGPTL7, EXOSC10, MASP2, TARDBP
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| The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
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| 81 | AIF1L, ANKHD1, ANKRD20A1, ANKRD27, ANKRD32, APH1B, APOLD1, ARMC4, ATXN10, C10orf10, C10orf10, C10orf118, C2orf14, C2orf16, C6orf60, C6orf62, C8orf71, CALCOCO1, CAMKK1, CCDC113, CCDC135, CCDC9, CCDC90B, CCNB2, CD99L2, CHPF, CLIC4, CLPB, CRELD1, CYBRD1, DDX47, DHRS7B, ESPN, FIP1L1, FLYWCH1, FYTTD1, GABARAPL1, GOLT1B, GPS2, GRIPAP1, HIGD1A, IER3IP1, KIF18A, KIRREL2, KLC2, LHX6, LMAN2L, MAF1, MED23, MIS12, MOB4, MYCBPAP, NCALD, NELF, NELFB, NRBF2, NRIP2, NRIP2, NRSN2, NUDT12, PCBD2, PMFBP1, PRPF31, PRSS23, QRSL1, RGMA, RGMB, RNF123, RNF146, RWDD3, SAMHD1, SECISBP2, SEMA4F, SERBP1, SERP1, SH3BP5L, SLC25A24, SLC25A39, SLC37A3, SLC41A2, SLC6A16, SMC6, SPEF1, STMN2, TARDBP, TBC1D3, TBL2, TFIP11, TIGD6, TIMMDC1, TMEM117, TMEM186, TNB, TRAF7, TRAPPC8, TSC22D3, TSPAN14, TWF2, UBA5, UNC50, WDR24, WDR37, WDR91, WSB1, YIPF3, ZC3H13, ZMYND12, ZMYND15, ZRANB3
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| 82 | ADIPOR1, AIG1, AMDHD2, ANKHD1, ANKRD20A1, ANKRD27, ANKRD32, APH1A, APH1B, APIP, APOLD1, ARS2, ASCC1, ATXN10, BOLA1, C10orf10, C14orf166, C19orf56, C20orf109, C20orf4, C2orf14, C2orf16, C6orf60, C6orf62, CALCOCO1, CAMKK1, CCDC113, CCDC53, CCDC9, CCNB2, CD99L2, CDK5RAP1, CDK5RAP1, CGI-96, CHMP5, CHPF, CIAO2B, CLIC4, CLPB, COPZ1, COQ4, COQ6, CRELD1, CUTC, CYBRD1, DDX47, DERA, DHRS7, DHRS7B, DHRS7B, DPH5, DTNB, DYNC1LI2, EEF1AKNMT, ELOVL1, EMC9, ERGIC3, ESPN, EXOSC1, EXOSC3, FAHD2A, FAM108B1, FAM18B, FAM32A, FAM82B, FCF1, FIP1L1, FLYWCH1, FYTTD1, GABARAPL1, GET4, GLOD4, GLRX2, GOLT1B, GOLT1B, GPR89A, GPS2, GRIPAP1, HDDC2, HDGFRP3, HIGD1A, IER3IP1, IFT52, ISOC1, KIF18A, KIF20B, KIRREL2, KL3, KLC2, LACTB2, LHX6, LMAN2L, LUC7L2, MAF1, MAGMAS, MECR, MED23, MED31, MEMO, METTL9, MIS12, MOABHD5, MOB4, MPC1, MRPL11, MRPL2, MRPL4, MRPL48, MRPS15, MRPS16, MRPS16P2, MRPS18C, MRPS23, MRPS33, MTCH1, MTERF3, MTO1, MYCBPAP, NCALD, NCIE2, NDUFAF1, NELF, NELFB, NFU1, NMD3, NOSIP, NRBF2, NRIP2, NRIP2, NRSN2, NUDT12, OTUD6B, PARVB, PCBD2, PHF20L1, PIGT, PMFBP1, PNAS-4, PRPF31, PRSS23, PTRH2, QRSL1, RBMX2, RGMA, RGMB, RNF103-CHMP3, RNF123, RNF146, RRNAD1, RRP15, RWDD1, RWDD3, SAMHD1, SAMM50, SCCPDH, SECISBP2, SEMA4F, SERBP1, SERBP1, SERP1, SH3BP5L, SIDT2, SLC25A24, SLC25A39, SLC35C2, SLC37A3, SLC41A2, SLC6A16, SLMO2, SMC6, SPEF1, SQRDL, STARD10, STMN2, SYF2, TARDBP, TBC1D3, TBL2, TFB1M, TFIP11, THAP4, THAP4, TIGD6, TIMMDC1, TMED5, TMED7, TMEM47, TPPP3, TRAF7, TRAPPC12, TRAPPC4, TRMT6, TRNT1, TSC22D3, TSPAN14, TWF2, UBE1DC1, UBE2J1, UCHL5, UNC50, USP39, UTP11L, VPS36, WDR37, WDR50, WDR91, WSB1, YARS2, YIPF3, YPEL5, ZC2HC1A, ZC3H13, ZDHHC9, ZMYND12, ZMYND15, ZRANB3
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| 83 | KIF22, TARDBP
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| Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.
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| 84 | TARDBP
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| Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
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