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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

MYL1

contributors: mct - updated : 07-09-2016

HGNC name	myosin, light polypeptide 1, alkali; skeletal, fast
HGNC id	7582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive pharynx       highly Reproductive male system prostate     highly Respiratory lung         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transcriptional domains with left and right compoment
	two heavy chains and four light chains
	three EF-hand domains

mono polymer

hexamer

HOMOLOGY

interspecies	homolog to murine Mylf
	homolog to Drosophila Mlc-c
	homolog to C.elegans T12D8.6

Homologene

FAMILY

CATEGORY

motor/contractile , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	regulatory light chain of myosin
	play a vital role in embryonic, fetal, and adult skeletal muscle development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

hexameric ATPase cellular motor protein composed of two heavy chains, two nonphosphorylable alkali light chains and two phosphorylable regulatory light chains

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

PARD3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MYL1 phosphorylation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other	polymorphism of intron MYL1 was associated with endurance performance, specifically in endurance trainability

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS