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FLASH GENE
Symbol MYL1 contributors: mct - updated : 07-09-2016
HGNC name myosin, light polypeptide 1, alkali; skeletal, fast
HGNC id 7582
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivepharynx   highly
Reproductivemale systemprostate  highly
Respiratorylung    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transcriptional domains with left and right compoment
  • two heavy chains and four light chains
  • three EF-hand domains
  • mono polymer hexamer
    HOMOLOGY
    interspecies homolog to murine Mylf
    homolog to Drosophila Mlc-c
    homolog to C.elegans T12D8.6
    Homologene
    FAMILY
    CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulatory light chain of myosin
  • play a vital role in embryonic, fetal, and adult skeletal muscle development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component hexameric ATPase cellular motor protein composed of two heavy chains, two nonphosphorylable alkali light chains and two phosphorylable regulatory light chains
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • PARD3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MYL1 phosphorylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
  • polymorphism of intron MYL1 was associated with endurance performance, specifically in endurance trainability
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS