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FLASH GENE

Symbol

CD200

contributors: mct - updated : 30-08-2014

HGNC name	CD200 antigen
HGNC id	7203

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in renal carcinoma, head and neck carcinoma, testicular cancer, malignant mesothelioma, colon carcinoma, MGUS/smoldering myeloma, and in chronic lymphocytic leukemia tumoral     --over   similarly overexpressed in human melanoma cell lines and primary tumors (Petermann 2007) constitutional     --over   enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy tumoral     --over   in vascular endothelium surrounding cutaneous squamous cell carcinoma constitutional     --other   aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity

Susceptibility

Variant & Polymorphism

Candidate gene	CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia (all B-CLL cells were CD200+ both in lymph nodes and in BM while all MCL cells were negative) (Palumbo 2009)
Marker	immunohistochemical expression of CD200 is a useful marker for the diagnosis and follow-up of plasma cell myeloma (PCM)
Therapy target
	System Type Disorder Pubmed cancer skin   anti-CD200 neutralizing antibody alone or in combination with SMO antagonists might be beneficial in the treatment of inoperable and metastatic basal cell carcinoma cancer     being a potential therapeutic target and prognostic factor for a large array of malignancies cancer skin   CD200 and CD200R1 are potential therapeutic target for metastatic melanoma neurology neurodegenerative Parkinson/dementia Parkinsonism it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways

ANIMAL & CELL MODELS

Cd200-deficient mice express an inflammatory phenotype exhibiting increased macrophage or microglial activation in models of arthritis, encephalitis, and uveoretinitis