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FLASH GENE
Symbol CD200 contributors: mct - updated : 30-08-2014
HGNC name CD200 antigen
HGNC id 7203
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Nervousbrain   highly Homo sapiens
 brainlimbic systemhippocampus  
 brainhindbraincerebellum  
 brainforebraincerebral cortex  
 spinal cord    
Reproductivefemale systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
Lymphoid/ImmuneT cell
Nervousastrocyte Homo sapiens
Nervousneuron Homo sapiens
Nervousoligodendrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one immunoglobulin V-Type
  • one immunoglobulin-like C2-type domain
  • a short cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane glycoprotein
    basic FUNCTION
  • may regulate myeloid cell activity in a variety of
  • tissues
  • involved in regulation of macrophage function
  • playing an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion
  • with CD200R1, having a role in regulating bone formation
  • suppresses immune activity via its receptor, CD200R1 (CD200-CD200R1 interactions have recently been considered to contribute to the "immune privileged" status of the central nervous system) (Koning 2009)
  • CD200R1/CD200 pathway is up-regulated in arthritis and plays a significant physiological role in regulating the severity of disease
  • neuroinflammatory changes that result from CD200 deficiency have a negative impact on synaptic plasticity
  • can regulate the activation threshold of inflammatory immune responses, polarize cytokine production, and maintain immune homeostasis (pMID: 22621248)
  • play a major role in the regulation of bone resorption and bone physiology and that the CD200-CD200R couple could be a new target to control bone diseases
  • CD200-CD200R1 interaction is involved in the anti-inflammatory and neuroprotective action of PPARG agonists
  • might play a role in the immune response in the pathogenesis of bullous pemphigoid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component glycoprotein constituent of membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with OX2R
  • ligand of CD200R1 (CD200-CD200R axis is a putative regulator of bone mass, via the formation of osteoclasts)
  • interaction between CD200, and CD200R1, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions
  • cell & other
    REGULATION
    Other regulated by C/EBPbeta (important role in transcriptional regulation of CD200)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in renal carcinoma, head and neck carcinoma, testicular cancer, malignant mesothelioma, colon carcinoma, MGUS/smoldering myeloma, and in chronic lymphocytic leukemia
    tumoral     --over  
    similarly overexpressed in human melanoma cell lines and primary tumors (Petermann 2007)
    constitutional     --over  
    enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy
    tumoral     --over  
    in vascular endothelium surrounding cutaneous squamous cell carcinoma
    constitutional     --other  
    aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia (all B-CLL cells were CD200+ both in lymph nodes and in BM while all MCL cells were negative) (Palumbo 2009)
    Marker
  • immunohistochemical expression of CD200 is a useful marker for the diagnosis and follow-up of plasma cell myeloma (PCM)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    anti-CD200 neutralizing antibody alone or in combination with SMO antagonists might be beneficial in the treatment of inoperable and metastatic basal cell carcinoma
    cancer  
    being a potential therapeutic target and prognostic factor for a large array of malignancies
    cancerskin 
    CD200 and CD200R1 are potential therapeutic target for metastatic melanoma
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways
    ANIMAL & CELL MODELS
  • Cd200-deficient mice express an inflammatory phenotype exhibiting increased macrophage or microglial activation in models of arthritis, encephalitis, and uveoretinitis