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FLASH GENE

Symbol

CD200

contributors: mct - updated : 30-08-2014

HGNC name	CD200 antigen
HGNC id	7203

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	30.47 kb     6 Exon(s)

regulatory sequence	Promoter
text structure	positive regulatory domains (PRDs) were identified in the core promoter

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005944 6 - 2226 NP_005935 - 269 - 2003 1285314 NM_001004196 7 - 2301 NP_001004196 - 294 - 2003 1285314

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Hearing/Equilibrium ear inner cochlea   highly Nervous brain       highly Homo sapiens   brain limbic system hippocampus       brain hindbrain cerebellum       brain forebrain cerebral cortex       spinal cord         Reproductive female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Lymphoid/Immune T cell Nervous astrocyte Homo sapiens Nervous neuron Homo sapiens Nervous oligodendrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one immunoglobulin V-Type
	one immunoglobulin-like C2-type domain
	a short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane glycoprotein

basic FUNCTION	may regulate myeloid cell activity in a variety of
	tissues
	involved in regulation of macrophage function
	playing an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion
	with CD200R1, having a role in regulating bone formation
	suppresses immune activity via its receptor, CD200R1 (CD200-CD200R1 interactions have recently been considered to contribute to the "immune privileged" status of the central nervous system) (Koning 2009)
	CD200R1/CD200 pathway is up-regulated in arthritis and plays a significant physiological role in regulating the severity of disease
	neuroinflammatory changes that result from CD200 deficiency have a negative impact on synaptic plasticity
	can regulate the activation threshold of inflammatory immune responses, polarize cytokine production, and maintain immune homeostasis (pMID: 22621248)
	play a major role in the regulation of bone resorption and bone physiology and that the CD200-CD200R couple could be a new target to control bone diseases
	CD200-CD200R1 interaction is involved in the anti-inflammatory and neuroprotective action of PPARG agonists
	might play a role in the immune response in the pathogenesis of bullous pemphigoid

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

glycoprotein constituent of membrane

INTERACTION

DNA

RNA

small molecule

protein	interacting with OX2R
	ligand of CD200R1 (CD200-CD200R axis is a putative regulator of bone mass, via the formation of osteoclasts)
	interaction between CD200, and CD200R1, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions

cell & other

REGULATION

Other

regulated by C/EBPbeta (important role in transcriptional regulation of CD200)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in renal carcinoma, head and neck carcinoma, testicular cancer, malignant mesothelioma, colon carcinoma, MGUS/smoldering myeloma, and in chronic lymphocytic leukemia tumoral     --over   similarly overexpressed in human melanoma cell lines and primary tumors (Petermann 2007) constitutional     --over   enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy tumoral     --over   in vascular endothelium surrounding cutaneous squamous cell carcinoma constitutional     --other   aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity

Susceptibility

Variant & Polymorphism

Candidate gene	CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia (all B-CLL cells were CD200+ both in lymph nodes and in BM while all MCL cells were negative) (Palumbo 2009)
Marker	immunohistochemical expression of CD200 is a useful marker for the diagnosis and follow-up of plasma cell myeloma (PCM)
Therapy target
	System Type Disorder Pubmed cancer skin   anti-CD200 neutralizing antibody alone or in combination with SMO antagonists might be beneficial in the treatment of inoperable and metastatic basal cell carcinoma cancer     being a potential therapeutic target and prognostic factor for a large array of malignancies cancer skin   CD200 and CD200R1 are potential therapeutic target for metastatic melanoma neurology neurodegenerative Parkinson/dementia Parkinsonism it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways

ANIMAL & CELL MODELS

Cd200-deficient mice express an inflammatory phenotype exhibiting increased macrophage or microglial activation in models of arthritis, encephalitis, and uveoretinitis