Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

IL8

contributors: mct - updated : 27-10-2018

HGNC name	interleukin 8
HGNC id	6025

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Endocrine pancreas       highly Reproductive male system prostate     lowly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic       highly Epithelial barrier/lining epidermis

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Reproductive epithelial cell

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

intercrine alpha (chemokine CxC) family

CATEGORY

chaperone/stress , signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	neutrophil activating peptide 1, monocyte-derived neutrophil chemotactic factor
	involved in the benign prostatic hyperplasia
	functioningas a chemoattractant, and is also a potent angiogenic factor
	potential role of IL8 to determine the fate of other inflammatory molecules, such as IL18, within the inflammatory milieu of the cystic fibrosis lung
	chemokine with a defining CXC amino acid motif, known to possess tumorigenic and proangiogenic properties
	signaling role for lactate in endothelial cells and they identify the lactate/NFkappaB/IL8 pathway as an important link between tumor metabolism and angiogenesis
	essential role of IL8 signaling for the acquisition and/or maintenance of the mesenchymal and invasive features of Brachyury-overexpressing tumor cells
	IL8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
	plays a neuroprotective role in the AD pathogenesis probably by modulating neuronal functions
	protects neurons through an autocrine mechanism and that it induces the synthesis and/or release of neurotrophic factors
	acidic histone chaperone that regulates proper CENPB binding to nucleosomes
	IL8 is a proinflammatory chemokine important for the regulation of inflammatory and immune responses via its interaction with G-protein coupled receptors, including CXC receptor 1 (CXCR1)
	is a key mediator of innate immune and inflammatory responses
	IL8, a potent neutrophil-activating chemokine, exerts its function by activating the CXCR1 receptor that belongs to class A G protein-coupled receptors (GPCRs)
	IL8, IL6, IL5 might likely play central roles in cytokine storms associated with COVID-19

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	N- and C-terminal peptides of IL8 are ligands for IL8RA and IL8RB
	interacting with DEFA1 (DEFA1 mainly enhanced the expression of IL8 in epithelial cells, whereas it enhanced transforming growth factor-beta and vascular endothelial growth factor expressions in lung fibroblasts)
	CFTR function is required to suppress IL8 secretion
	TMED1 is required for optimal IL33-induced IL8 and IL6 production
	inhibited the non-specific binding of CENPB to nucleosomes and apparently stimulated CENPB binding to its cognate CENPB box DNA in nucleosomes
	IL8 plays a major role in neutrophil chemotaxis caused by alveolar macrophage-derived conditioned media, and this is most effectively inhibited by dual antagonism of CXCR1 and CXCR2
	BTC significantly increased the production of IL8 through the activation of the EGFR-PI3K/Akt-Erk signal pathway in lung cancer cells
	IL8/CXCR1 axis is associated with the cancer stem cell (CSC)-like properties of pancratic cancer cells and prognosis in human pancreatic cancer
	IL8 exists as monomers and dimers but monomer alone binds CXCR1 with high affinity
	IL8 function involves binding two distinct CXCR1 sites - the N-terminal domain (Site-I) and the extracellular/transmembrane domain (Site-II)
	extracellular acidification stimulates GPR68 mediated IL8 production in human pancreatic beta cells
	role for CXCL1 and IL8 in CF lung disease severity and identify STAT3 as a modulating pathway
	CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTP&
	8209;mediated ICAM1 and IL8 mRNA decay
	TMPRSS11D stimulates IL8 synthesis in airway epithelial cells via F2RL1 and could help to amplify inflammation in chronic respiratory tract disease

cell & other

REGULATION

induced by	Prokineticin 1 (induces CCL4, CXCL1 and IL8 in monocytes but not in macrophages and dendritic cells) (Monnier 2008)
		ENTPD1 (inhibition of ENTPD1 markedly increases IL8 production by TLR-stimulated human neutrophils)
		neurotoxins such as Abeta, as well as pro-inflammatory cytokines such as TNF, inducing CXCL8 production in neurons and Abeta and/or IL1B in glial cells

repressed by

oestradiol

Other	SNAI1 activated the expression of IL8 by direct binding to its E3/E4 E-boxes (

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in ulcerative colitis and Crohn's disease and in osteoarthritis cartilage tumoral     --over   in mesothelioma tumoral     --over   colorectal cancer (CRC), and is associated with poor prognosis constitutional     --over   significantly higher IL8 levels in Alzheimer disease brain tissue lysates as compared to those of age-matched controls

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon important therapeutic target in colorectal cancer

ANIMAL & CELL MODELS