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FLASH GENE

Symbol

KEAP1

contributors: mct - updated : 24-11-2016

HGNC name	kelch-like ECH-associated protein 1
HGNC id	23177

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Keap-1 deficient mice died postnatally, Nrf2 constitutively accumulates in the nucleus to stimulate transcription of cytoprotective genes
	phenotype of Keap1 -/- mouse skin is similar to that of autosomal recessive congenital ichtyosis (ARCI) (which is located at the same locus)
	Keap1-null mutant mice are juvenile-lethal due to hyperkeratosis of the esophagus