| 1 | KEAP1, NFE2L2, NIBAN2
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| FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells
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| Schmidlin CJ, Tian W, Dodson M, Chapman E, Zhang DD.
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| Mol Carcinog. May;60(5):331-341. doi: 10.1002/mc.23295. Epub 2021 Mar 8 2021
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| 2 | KEAP1, NFE2L2, PGAM5
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| A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
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| O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM.
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| J Cell Sci 130(20):3467-3480. doi: 10.1242/jcs.203216. Epub 2017 Aug 24.
2017
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| 3 | KEAP1, NTRK2, RUNX3
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| TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression.
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| Kim MS, Lee WS, Jin W.
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| Mol Cells 39(3):258-65. doi: 10.14348/molcells.2016.2310.
2016
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| 4 | KEAP1
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| Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
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| Cleasby A, Yon J, Day PJ, Richardson C, Tickle IJ, Williams PA, Callahan JF, Carr R, Concha N, Kerns JK, Qi H, Sweitzer T, Ward P, Davies TG.
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| PLoS One 9(6):e98896. doi: 10.1371/journal.pone.0098896. eCollection 2014.
2014
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| 5 | KEAP1, NFE2L2
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| Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.
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| Murakami S, Shimizu R, Romeo PH, Yamamoto M, Motohashi H.
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| Genes Cells 19(3):239-53. doi: 10.1111/gtc.12126. Epub 2014 Jan 21.
2014
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| 6 | KEAP1, NFE2L2, SQSTM1
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| Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
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| Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
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| Mol Cell 51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5.
2013
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| 7 | KEAP1, NFE2L2
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| The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.
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| Kanzaki H, Shinohara F, Kajiya M, Kodama T.
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| J Biol Chem 288(32):23009-20. doi: 10.1074/jbc.M113.478545. Epub 2013 Jun 25. Erratum in: J Biol Chem. 2014 Feb 28;289(9):5536.
2013
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| 8 | KEAP1, NFE2L2, USP15
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| USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
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| Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD.
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| Mol Cell 51(1):68-79. doi: 10.1016/j.molcel.2013.04.022. Epub 2013 May 30.
2013
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| 9 | KEAP1
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| Identification of a KEAP1 germline mutation in a family with multinodular goitre.
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| Teshiba R, Tajiri T, Sumitomo K, Masumoto K, Taguchi T, Yamamoto K.
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| PLoS One 8(5):e65141. doi: 10.1371/journal.pone.0065141. Print 2013.
2013
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| 10 | KEAP1, NFE2L2
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| Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
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| Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
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| Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.
2013
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| 11 | KEAP1, NFE2L2
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| Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
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| Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
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| Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.
2013
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| 12 | AMER1, KEAP1, NFE2L2, SQSTM1
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| Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
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| Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
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| Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.
2013
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| 13 | KEAP1, SESN1, SESN2
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| Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
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| Bae SH, Sung SH, Oh SY, Lim JM, Lee SK, Park YN, Lee HE, Kang D, Rhee SG.
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| Cell Metab 17(1):73-84. doi: 10.1016/j.cmet.2012.12.002. Epub 2012 Dec 27.
2013
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| 14 | KEAP1, NFE2L2, PALB2
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| PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
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| Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B.
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| Mol Cell Biol 32(8):1506-17. doi: 10.1128/MCB.06271-11. Epub 2012 Feb 13.
2012
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| 15 | AMER1, KEAP1, NFE2L2
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| Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
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| Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT.
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| J Biol Chem 287(9):6539-50. doi: 10.1074/jbc.M111.316471. Epub 2012 Jan 3.
2012
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| 16 | BCL2, KEAP1, NFE2L2
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| Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
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| Niture SK, Jaiswal AK.
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| J Biol Chem 287(13):9873-86. doi: 10.1074/jbc.M111.312694. Epub 2012 Jan 24.
2012
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| 17 | KEAP1, NFE2L2
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| Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.
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| Palsamy P, Ayaki M, Elanchezhian R, Shinohara T.
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| Biochem Biophys Res Commun 423(3):542-8. doi: 10.1016/j.bbrc.2012.05.164. Epub 2012 Jun 7.
2012
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| 18 | KEAP1, NFE2L2
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| Keap1 degradation by autophagy for the maintenance of redox homeostasis.
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| Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
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| Proc Natl Acad Sci U S A 109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.
2012
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| 19 | KEAP1
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| INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis.
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| Niture SK, Jaiswal AK.
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| Cell Death Differ 18(3):439-51. Epub 2010 Sep 24.
2011
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| 20 | KEAP1, KPNA6
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| KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
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| Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD.
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| Mol Cell Biol 31(9):1800-11. Epub 2011 Mar 7.
2011
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| 21 | KEAP1, NFE2L2
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| Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer.
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| Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA.
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| Cancer Res 71(15):5081-9. Epub 2011 Jun 15.
2011
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| 22 | KEAP1, NFE2L2
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| Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
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| Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
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| Proc Natl Acad Sci U S A 107(7):2842-7. Epub 2010 Jan 27. 2010
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| 23 | KEAP1
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| KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
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| Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC.
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| Mol Cell 36(1):131-40.PMID: 19818716 [ 2009
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| 24 | KEAP1, NFE2L2
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| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
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| Hayes JD, McMahon M.
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| Trends Biochem Sci 34(4):176-88. Epub 2009 Mar 25. Review.PMID: 19321346 2009
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| 25 | CUL3, KEAP1, NFE2L2
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| Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
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| Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.
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| Proc Natl Acad Sci U S A 105(36):13568-73. Epub 2008 Aug 29. 2008
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| 26 | KEAP1
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| Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues.
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| Wang R, An J, Ji F, Jiao H, Sun H, Zhou D.
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| Biochem Biophys Res Commun 373(1):151-4. Epub 2008 Jun 12.
2008
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| 27 | KEAP1, NFE2L2
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| A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity.
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| Nioi P, Nguyen T.
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| Biochem Biophys Res Commun 362(4):816-21. Epub 2007 Aug 27. 2007
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| 28 | KEAP1
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| Subcellular localization and cytoplasmic complex status of endogenous Keap1.
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| Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M.
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| Genes Cells 12(10):1163-78.PMID: 17903176 2007
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| 29 | KEAP1, NFE2L2
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| Mechanistic studies of the Nrf2-Keap1 signaling pathway.
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| Zhang DD.
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| Drug Metab Rev 38(4):769-89. Review.PMID: 17145701 2006
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| 30 | KEAP1
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| Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
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| Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML, Guis D.
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| Free Radic Biol Med. Apr 1;32(7):650-62. Erratum in: Free Radic Biol Med 2002 Jul 31;33(1):149 2002
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| 31 | KEAP1, MYO7A
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| A human homologue of Drosophila kelch associates with myosin-VIIa in specialized adhesion junctions.
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| Velichkova M, Guttman J, Warren C, Eng L, Kline K, Vogl AW, Hasson T.
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| Cell Motil Cytoskeleton 51(3):147-64. 2002
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| 32 | KEAP1
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| Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.
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| Sekhar KR, Yan XX, Freeman ML.
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| Oncogene 21(44):6829-34. 2002
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| 33 | KEAP1, NFE2L2
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| The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
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| Zipper LM, Mulcahy RT.
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| J Biol Chem 277(39):36544-52. Epub 2002 Jul 26.PMID: 12145307 2002
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| 34 | KEAP1
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| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
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| Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M.
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| Genes Dev 13(1):76-86. 1999
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| 35 | ARID4B, BOP1, CACNA2D2, CCT5, CKAP5, CTR9, DCLRE1A, DELE1, DGKD, DHX34, EIF3A, EIF4A3, EMC1, EMC2, EXOSC7, FAM175B, FAM53B, GANAB, GGA3, GIT2, GPD1L, INPP5E, KEAP1, KIAA0082, KIAA0087, KIAA0114, KIAA0125, MAD2L1BP, MBTPS1, METAP1, MORC3, NCAPD2, NUP93, OEATC1, PASK, PMPCA, PRDX6, PSMD6, PUM1, RBM10, SAFB2, SART3, SCRIB, SERTAD2, SNRK, SPCS2, TAGLN2, THRAP4, TRIM14, TTLL12, UBAP2L, UBE4A, URB2, ZC3H3
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| Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
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| Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S,Ishikawa K, Kawarabayasi Y, Kotani H, et al.
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| DNA Res 2(1):37-43. 1995
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