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FLASH GENE
Symbol PODN contributors: - updated : 10-02-2006
HGNC name podocan
HGNC id 23174
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal cysteine-rich cluster pattern
  • a leucine-rich-repeat (LRR) domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus LOC313483
    ortholog to murine Podn
    Homologene
    FAMILY small leucine-rich repeat (SLR) protein family
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text cytoplasmic in glomeruli, secreted from podocytes
    basic FUNCTION
  • proteoglycan that may regulate and maintain extracellular matrix collagen fibrils
  • may have a potential role in growth regulation in cardiovascular tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind type 1 collagen
    cell & other
    REGULATION
    Other up-regulated in HIV transgenic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the sclerotic glomerular lesion of HIVAN
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS