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FLASH GENE

Symbol

IRF2BP2

contributors: mct/npt/pgu - updated : 18-05-2009

HGNC name	interferon regulatory factor 2 binding protein 2
HGNC id	21729

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q42.3      Physical location : 234.740.016 - 234.745.271
Synonym symbol(s)	IRF-2BP2, DIF-1

DNA

TYPE	functioning gene
STRUCTURE	5.26 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001077397 2 - 4629 NP_001070865 - 571 - 2003 12799427 NM_182972 2 - 4677 NP_892017 - 587 - 2003 12799427

EXPRESSION

Rna function	high levels of IRF2BP2 mRNA in adult heart and skeletal muscles
Type	widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Lymphoid/Immune lymph node       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     predominantly Muscular striatum skeletal   lowly Homo sapiens Muscular striatum cardiac     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal zinc finger
	a phosphorylation-dependent nuclear localization motif (
	a C-terminal RING finger domain of the C3HC4 type

HOMOLOGY

Homologene

FAMILY

IRF2BP family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	found in the nucleus of cardiac and skeletal muscle cells (nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS)

basic FUNCTION	corepressor for IRF2
	can inhibit both enhancer-ativated and basal transcription in an IRF2-dependent manner
	might be part of a new feedback-loop for the cells after p53 activation, increasing the threshold for induction of apoptosis, but also inhibiting the progression of cell cycle, possibly to allow repair of damaged DNA
	required to activate VEGFA expression
	ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles
	represses the NFATC2-dependent transactivation of NFAT-responsive promoters
	negative regulator of the NFATC2 transcription factor, suggesting that NFATC2 repression occurs at the transcriptional level
	muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with IRF2
	direct target gene of TP53, influencing the TP53-mediated cellular decision (promotes cell-cycle arrest and seems to interfere with TP53-mediated apoptosis after chemotherapeutic treatment)
	cellular target of ITGB3BP, identified as a transcriptional repressor
	interaction of IRF2BP2, IRF2BP1, and EAP1 occurs through the conserved C4 zinc fingers of these proteins, and forms DIF-1 complex
	specifically interacts with the C-terminal domain of NFATC2 among the NFAT family members

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS