Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CD109

contributors: mct - updated : 15-03-2016

HGNC name	CD109 molecule
HGNC id	21685

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells tumoral     --over   in cervical squamous cell carcinomas than in endometrial adenocarcinomas tumoral     --over   significantly overexpressed in pancreatic tumors compared to normal pancreas tumoral     --over   in cutaneous squamous cell carcinoma constitutional       gain of function in scleroderma or systemic sclerosis (SSc)

Susceptibility

Variant & Polymorphism SNP	Gov alleles differ by an A to C single nucleotide polymorphism at position 2108 of the coding region, resulting in a tyr/ser substitution at CD109 amino acid 703 and this SNP correlates with the Gov phenotype

Candidate gene	useful marker for the diagnosis of invasive breast and prostate carcinomas
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   potential therapeutic value for the treatment of Scleroderma or systemic sclerosis (SSc)

ANIMAL & CELL MODELS