Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD109 contributors: mct - updated : 15-03-2016
HGNC name CD109 molecule
HGNC id 21685
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells
tumoral     --over  
in cervical squamous cell carcinomas than in endometrial adenocarcinomas
tumoral     --over  
significantly overexpressed in pancreatic tumors compared to normal pancreas
tumoral     --over  
in cutaneous squamous cell carcinoma
constitutional       gain of function
in scleroderma or systemic sclerosis (SSc)
Susceptibility
Variant & Polymorphism SNP Gov alleles differ by an A to C single nucleotide polymorphism at position 2108 of the coding region, resulting in a tyr/ser substitution at CD109 amino acid 703 and this SNP correlates with the Gov phenotype
Candidate gene useful marker for the diagnosis of invasive breast and prostate carcinomas
Marker
Therapy target
SystemTypeDisorderPubmed
dermatologyskin 
potential therapeutic value for the treatment of Scleroderma or systemic sclerosis (SSc)
ANIMAL & CELL MODELS