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FLASH GENE
Symbol TSSK2 contributors: mct - updated : 14-09-2020
HGNC name testis specific serine threonine kinase 2
HGNC id 11401
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved kinase domains typical of the superfamily of Ser/Thr kinases
    • HOMOLOGY
    interspecies homolog to murine Stk22b
    Homologene
    FAMILY testis-specific serine/threonine (Ser/Thr) kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase, involved in spermatogenesis (see D22S1572)
  • might play a role in sperm function (as other members of this family)
  • TSSK1B and TSSK2 may perform at least partly differential functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSKS
  • SPAG16 is a TSSK2 substrate
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male idiopathic infertility
    Variant & Polymorphism other
  • allele G of c.80A>G (rs3747052) and allele T of c.774C>T (rs1052756) seem to be risk factors for the development of spermatogenic impairment
    • Candidate gene
  • candidate male contraceptive target
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is an important target for reversible male contraception
    ANIMAL & CELL MODELS