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FLASH GENE
Symbol TSSK2 contributors: mct - updated : 14-09-2020
HGNC name testis specific serine threonine kinase 2
HGNC id 11401
DNA
TYPE functioning gene
STRUCTURE 1.31 kb     1 Exon(s)
MAPPING cloned Y linked   status provisional
Map see DGCR
regionally located transcript DGS-G, 1.8kb, from the DGCR minimal critical region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1315 - 358 - 2016 26777341
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion TSSK1, TSSK2 and TSSK6 were detected in human sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved kinase domains typical of the superfamily of Ser/Thr kinases
  • HOMOLOGY
    interspecies homolog to murine Stk22b
    Homologene
    FAMILY testis-specific serine/threonine (Ser/Thr) kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase, involved in spermatogenesis (see D22S1572)
  • might play a role in sperm function (as other members of this family)
  • TSSK1B and TSSK2 may perform at least partly differential functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSKS
  • SPAG16 is a TSSK2 substrate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male idiopathic infertility
    Variant & Polymorphism other
  • allele G of c.80A>G (rs3747052) and allele T of c.774C>T (rs1052756) seem to be risk factors for the development of spermatogenic impairment
  • Candidate gene
  • candidate male contraceptive target
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is an important target for reversible male contraception
    ANIMAL & CELL MODELS