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FLASH GENE

Symbol

TSSK2

contributors: mct - updated : 14-09-2020

HGNC name	testis specific serine threonine kinase 2
HGNC id	11401

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.31 kb     1 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map

see DGCR

regionally located

transcript DGS-G, 1.8kb, from the DGCR minimal critical region

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_053006 1 - 1315 NP_443732 - 358 - 2016 26777341

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     predominantly Homo sapiens

cell lineage
cell lines
fluid/secretion	TSSK1, TSSK2 and TSSK6 were detected in human sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved kinase domains typical of the superfamily of Ser/Thr kinases

HOMOLOGY

interspecies

homolog to murine Stk22b

Homologene

FAMILY

testis-specific serine/threonine (Ser/Thr) kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus

basic FUNCTION	serine/threonine kinase, involved in spermatogenesis (see D22S1572)
	might play a role in sperm function (as other members of this family)
	TSSK1B and TSSK2 may perform at least partly differential functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TSKS
	SPAG16 is a TSSK2 substrate

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to male idiopathic infertility

Variant & Polymorphism other	allele G of c.80A>G (rs3747052) and allele T of c.774C>T (rs1052756) seem to be risk factors for the development of spermatogenic impairment

Candidate gene	candidate male contraceptive target
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   is an important target for reversible male contraception

ANIMAL & CELL MODELS