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FLASH GENE
Symbol TSSK2 contributors: mct - updated : 14-09-2020
HGNC name testis specific serine threonine kinase 2
HGNC id 11401
Location 22q11.21      Physical location : 19.118.320 - 19.120.136
Synonym name
  • serine/threonine kinase 22B (spermiogenesis associated)
  • testis specific serine threonine kinase 2
  • spermiogenesis associated 2
  • testicular secretory protein Li 61
    • Synonym symbol(s) TSKL, DGSG, SPOGA2, STK22B, FLJ38613
    EC.number 2.7.1.37/ 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 1.31 kb     1 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map see DGCR
    regionally located transcript DGS-G, 1.8kb, from the DGCR minimal critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1315 - 358 - 2016 26777341
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion TSSK1, TSSK2 and TSSK6 were detected in human sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved kinase domains typical of the superfamily of Ser/Thr kinases
    • HOMOLOGY
    interspecies homolog to murine Stk22b
    Homologene
    FAMILY testis-specific serine/threonine (Ser/Thr) kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase, involved in spermatogenesis (see D22S1572)
  • might play a role in sperm function (as other members of this family)
  • TSSK1B and TSSK2 may perform at least partly differential functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSKS
  • SPAG16 is a TSSK2 substrate
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male idiopathic infertility
    Variant & Polymorphism other
  • allele G of c.80A>G (rs3747052) and allele T of c.774C>T (rs1052756) seem to be risk factors for the development of spermatogenic impairment
    • Candidate gene
  • candidate male contraceptive target
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is an important target for reversible male contraception
    ANIMAL & CELL MODELS