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FLASH GENE

Symbol

VGLL2

contributors: mct - updated : 06-07-2021

HGNC name	vestigial like 2 (Drosophila)
HGNC id	20232

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       VGLL2/NCOA2 fusions in pediatric spindle cell/sclerosing rhabdomyosarcoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Vgll2 (-/-) mice presented an increased number of fast-twitch type IIb fibers and exhibited a down-regulation of slow type I myosin heavy chain (MyHC) gene, Myh7, which resulted in exercise intolerance