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FLASH GENE

Symbol

HOMEZ

contributors: mct/npt - updated : 28-01-2009

HGNC name	homeobox and leucine zipper encoding
HGNC id	20164

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	multiple alternatively spliced variants encoding two distinct isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 3741 - 550 - Beausoleil (2004)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	lung, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three atypical homeodomains
	two leucine zipper-like motifs
	a putative nuclear localization signal
	an acidic domain

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

ortholog to murine Homez

Homologene

FAMILY

ZHX family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

may function as a transcriptional regulator

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with HOXC8

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS