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FLASH GENE
Symbol HOMEZ contributors: mct/npt - updated : 28-01-2009
HGNC name homeobox and leucine zipper encoding
HGNC id 20164
DNA
TYPE functioning gene
STRUCTURE 12.39 kb     2 Exon(s)
motif repetitive sequence   ALU
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text multiple alternatively spliced variants encoding two distinct isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3741 - 550 - Beausoleil (2004)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three atypical homeodomains
  • two leucine zipper-like motifs
  • a putative nuclear localization signal
  • an acidic domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Homez
    Homologene
    FAMILY
  • ZHX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as a transcriptional regulator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with HOXC8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS