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FLASH GENE

Symbol

NGF

contributors: mct/npt/pgu - updated : 02-06-2017

HGNC name	nerve growth factor (beta polypeptide)
HGNC id	7808

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HSAN5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   levels of both NGF protein in seminal plasma and NTRK1 mRNA in spermatozoa are low in samples from oligoasthenozoospermic men constitutional     --over   elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis

Susceptibility

to Alzheimer disease-like neurodegeneration, including cortical atrophy, memory deficits and amyloid deposits (NGF knockdown) to eating disorder to primary dysmenorrhoea

Variant & Polymorphism SNP , other	mutation loss of function in Alzheimer disease-like neurodegeneration
	rs7523831 near NGF confer risk for primary dysmenorrhoea

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast targeting NGF in breast cancer may have therapeutic ramifications

ANIMAL & CELL MODELS