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FLASH GENE
Symbol NGF contributors: mct/npt/pgu - updated : 02-06-2015
HGNC name nerve growth factor (beta polypeptide)
HGNC id 7808
ASSOCIATED DISORDERS
corresponding disease(s) HSAN5
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
levels of both NGF protein in seminal plasma and NTRK1 mRNA in spermatozoa are low in samples from oligoasthenozoospermic men
constitutional     --over  
elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis
Susceptibility
  • to Alzheimer disease-like neurodegeneration, including cortical atrophy, memory deficits and amyloid deposits (NGF knockdown)
  • to eating disorder
  • to primary dysmenorrhoea
  • Variant & Polymorphism SNP , other
  • mutation loss of function in Alzheimer disease-like neurodegeneration
  • rs7523831 near NGF confer risk for primary dysmenorrhoea
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    targeting NGF in breast cancer may have therapeutic ramifications
    ANIMAL & CELL MODELS