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FLASH GENE

Symbol

NGF

contributors: mct/npt/pgu - updated : 02-06-2017

HGNC name	nerve growth factor (beta polypeptide)
HGNC id	7808

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus     Homo sapiens Reproductive female system ovary       Homo sapiens   male system testis       Homo sapiens Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol   fibroblast Visual Muller cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two identical 118 AA beta chains

secondary structure

three subunits alpha beta gamma

mono polymer

homomer , dimer

isoforms

Precursor

initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form

HOMOLOGY

interspecies

homolog to murine beta NGF

Homologene

FAMILY

nerve growth factor (NGF-beta) family

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	angioneurin having a role in tissue repair and in fibrosis (stimulatory effect on skin and lung fibroblasts)
	functional interchangeability between the pro-peptides of NGF and NTF3 with respect to their role in assisting oxidative folding of the mature part
	NGF/proNGF have mitogenic and motogenic effects on oral mucosal keratinocytes and therefore may aid in the healing of oral wounds
	endogenous prosurvival factor for cardiomyocytes
	can act as protective factor against cytotoxic injuries
	relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity
	influences an inflammatory reaction by regulating neuropeptides, angiogenesis, cell trafficking molecules, and T cell activation
	essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain
	proNGF and mature NGF initiate opposing biological responses by utilizing both distinct and shared receptor components
	NGF-activation of NTRK1 stimulates an increase in VEGF transcription that is mediated by induction of HIF1A
	NGF reduced the synthesis of the cellular HIV-1 restriction factor APOBEC3G and also overrode its IFNG-induced up-regulation
	NGF signaling seems to play an important role in regulating neuronal KDR expression
	NGF and NTF3 collaborate to support development of sympathetic neurons
	activates retrograde transport of NTRK1 endosomes to support neuronal survival
	positive feedback regulation between LHX8, NTRK1, and NGF is likely an important regulatory mechanism for cholinergic functions of the septum
	plays a key role in the generation of pain and hyperalgesia and has been associated with migraine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SORT1 (essential role for NGFB-induced cell death)
	cognate ligand for the neurotrophic receptor NTRK1, promoting the interaction between CTBP2 and ACIN1 through triggering acinus phosphorylation by AKT1
	ALCAM synergizes with NGF to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system
	NGF is an important regulator for the synthesis and secretion of Activin-A and BTC from the beta cells
	NGF-induced upregulation of CALCA in orofacial pain induced by tooth movement is dependent on ATP6V0A1, and vesicle release (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HSAN5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   levels of both NGF protein in seminal plasma and NTRK1 mRNA in spermatozoa are low in samples from oligoasthenozoospermic men constitutional     --over   elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis

Susceptibility

to Alzheimer disease-like neurodegeneration, including cortical atrophy, memory deficits and amyloid deposits (NGF knockdown) to eating disorder to primary dysmenorrhoea

Variant & Polymorphism SNP , other	mutation loss of function in Alzheimer disease-like neurodegeneration
	rs7523831 near NGF confer risk for primary dysmenorrhoea

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast targeting NGF in breast cancer may have therapeutic ramifications

ANIMAL & CELL MODELS