Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NGF contributors: mct/npt/pgu - updated : 02-06-2013
HGNC name nerve growth factor (beta polypeptide)
HGNC id 7808
Corresponding disease
HSAN5 hereditary sensory and autonomic neuropathy, type V
Location 1p13.1      Physical location : 115.828.536 - 115.880.857
Synonym name
  • beta-nerve growth factor
  • nerve growth factor, beta subunit
  • Synonym symbol(s) NGFB, NTF1, Beta-NGF, HSAN5, MGC161426, MGC161428
    DNA
    TYPE functioning gene
    STRUCTURE 52.32 kb     3 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    Map see GNAI3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1052 26 241 - 2011 21768088
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemovary    Homo sapiens
     male systemtestis    Homo sapiens
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    VisualMuller cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two identical 118 AA beta chains
  • secondary structure three subunits alpha beta gamma
    mono polymer homomer , dimer
    isoforms Precursor initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form
    HOMOLOGY
    interspecies homolog to murine beta NGF
    Homologene
    FAMILY
  • nerve growth factor (NGF-beta) family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • angioneurin having a role in tissue repair and in fibrosis (stimulatory effect on skin and lung fibroblasts)
  • functional interchangeability between the pro-peptides of NGF and NTF3 with respect to their role in assisting oxidative folding of the mature part
  • NGF/proNGF have mitogenic and motogenic effects on oral mucosal keratinocytes and therefore may aid in the healing of oral wounds
  • endogenous prosurvival factor for cardiomyocytes
  • can act as protective factor against cytotoxic injuries
  • relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity
  • influences an inflammatory reaction by regulating neuropeptides, angiogenesis, cell trafficking molecules, and T cell activation
  • essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain
  • proNGF and mature NGF initiate opposing biological responses by utilizing both distinct and shared receptor components
  • NGF-activation of NTRK1 stimulates an increase in VEGF transcription that is mediated by induction of HIF1A
  • NGF reduced the synthesis of the cellular HIV-1 restriction factor APOBEC3G and also overrode its IFNG-induced up-regulation
  • NGF signaling seems to play an important role in regulating neuronal KDR expression
  • NGF and NTF3 collaborate to support development of sympathetic neurons
  • activates retrograde transport of NTRK1 endosomes to support neuronal survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SORT1 (essential role for NGFB-induced cell death)
  • cognate ligand for the neurotrophic receptor NTRK1, promoting the interaction between CTBP2 and ACIN1 through triggering acinus phosphorylation by AKT1
  • ALCAM synergizes with NGF to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system
  • NGF is an important regulator for the synthesis and secretion of Activin-A and BTC from the beta cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSAN5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    levels of both NGF protein in seminal plasma and NTRK1 mRNA in spermatozoa are low in samples from oligoasthenozoospermic men
    constitutional     --over  
    elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis
    Susceptibility
  • to Alzheimer disease-like neurodegeneration, including cortical atrophy, memory deficits and amyloid deposits (NGF knockdown)
  • to eating disorder
  • Variant & Polymorphism other mutation loss of function in Alzheimer disease-like neurodegeneration
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    targeting NGF in breast cancer may have therapeutic ramifications
    ANIMAL & CELL MODELS