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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CASP6

contributors: mct - updated : 30-03-2011

HGNC name	caspase 6, apoptosis-related cysteine protease
HGNC id	1507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in familial forms of AD, as previously observed in sporadic forms tumoral     --low   might contribute to the pathogenesis of gastric cancers

Susceptibility

to Alzheimer disease

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer pro-Casp6b is a potential inhibitor of pro-Casp6a activation and is a novel therapeutic target against neurodegeneration

ANIMAL & CELL MODELS