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FLASH GENE
Symbol CASP6 contributors: mct - updated : 30-03-2011
HGNC name caspase 6, apoptosis-related cysteine protease
HGNC id 1507
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
in familial forms of AD, as previously observed in sporadic forms
tumoral     --low  
might contribute to the pathogenesis of gastric cancers
Susceptibility to Alzheimer disease
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativealzheimer
pro-Casp6b is a potential inhibitor of pro-Casp6a activation and is a novel therapeutic target against neurodegeneration
ANIMAL & CELL MODELS