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FLASH GENE
Symbol CASP6 contributors: mct - updated : 30-03-2011
HGNC name caspase 6, apoptosis-related cysteine protease
HGNC id 1507
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
    • mono polymer heteromer , dimer
    isoforms Precursor precursor producing two subunits, large (18kDa) and small (16kDa) that dimerize
    HOMOLOGY
    Homologene
    FAMILY caspase family of cysteinyl-aspartate specific proteases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • cleaves poly(ADP-ribose) polymerase, as well as lamins
  • involved in the activation cascade of caspases responsible for apoptosis execution
  • could be an early instigator of neuronal dysfunction
  • regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry
  • playing a role in N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease
  • its activity may be involved in the clinical manifestation of Huntington and Parkinson diseases
  • can be activated and regulated through intramolecular self-cleavage
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer of a 18 kDa (p18) and a 11 kDa (p11) subunit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CASP3
  • CASP8
  • CASP10
  • IRAK3 is an important target for CASP6 (neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IRAK3)
  • BCL2L2 interacts with BAX and suppresses the CASP6 apoptotic cascade that fosters axonal degeneration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in familial forms of AD, as previously observed in sporadic forms
    tumoral     --low  
    might contribute to the pathogenesis of gastric cancers
    Susceptibility to Alzheimer disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    pro-Casp6b is a potential inhibitor of pro-Casp6a activation and is a novel therapeutic target against neurodegeneration
    ANIMAL & CELL MODELS