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FLASH GENE

Symbol

EIF2AK4

contributors: mct - updated : 31-08-2012

HGNC name	eukaryotic translation initiation factor 2 alpha kinase 4
HGNC id	19687

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     abrogation of EIF2AK4 expression significantly inhibited tumour growth neurology neurodegenerative alzheimer EIF2AK3, EIF2AK4 are potential therapeutic targets for treatment of individuals with Alzheimer disease

ANIMAL & CELL MODELS

	Gcn2-/- mice exhibited an increase in protein carbonylation, a marker of oxidative stress, in response to a long-term (24 weeks) leucine-imbalanced diet (ED&
	916;Leu)