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FLASH GENE
Symbol EIF2AK4 contributors: mct - updated : 31-08-2012
HGNC name eukaryotic translation initiation factor 2 alpha kinase 4
HGNC id 19687
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
abrogation of EIF2AK4 expression significantly inhibited tumour growth
neurologyneurodegenerativealzheimer
EIF2AK3, EIF2AK4 are potential therapeutic targets for treatment of individuals with Alzheimer disease
ANIMAL & CELL MODELS
  • Gcn2-/- mice exhibited an increase in protein carbonylation, a marker of oxidative stress, in response to a long-term (24 weeks) leucine-imbalanced diet (ED&
  • 916;Leu)