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FLASH GENE
Symbol PTGIS contributors: - updated : 15-09-2006
HGNC name prostaglandin I2 (prostacyclin) synthase
HGNC id 9603
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a tandem repeat of SP1 transcriptional binding sites
HOMOLOGY
Homologene
FAMILY p450 superfamily member
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • prostaglandin 12 synthase activity, strong vasodilatator inhibiting the growth of vascular smooth muscle cells and platelet agregation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by hypermethylation in colorectal cancer
    Susceptibility susceptibility factor for hypertension
    Variant & Polymorphism other splicing mutation in hypertension
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS