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FLASH GENE
Symbol PTGIS contributors: - updated : 15-09-2006
HGNC name prostaglandin I2 (prostacyclin) synthase
HGNC id 9603
Location 20q13.1-q13.3      Physical location : 48.120.412 - 48.184.707
Synonym name prostacyclin synthase
Synonym symbol(s) PGIS, PSTCS, CYP8, CYP8A1, MGC126858, MGC126860, PTGI
EC.number 5.3.99.4
DNA
TYPE functioning gene
STRUCTURE 64.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemovary  highly
 female systemuterus  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a tandem repeat of SP1 transcriptional binding sites
HOMOLOGY
Homologene
FAMILY p450 superfamily member
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • prostaglandin 12 synthase activity, strong vasodilatator inhibiting the growth of vascular smooth muscle cells and platelet agregation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by hypermethylation in colorectal cancer
    Susceptibility susceptibility factor for hypertension
    Variant & Polymorphism other splicing mutation in hypertension
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS