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FLASH GENE

Symbol

GPBAR1

contributors: mct - updated : 21-03-2018

HGNC name	G protein-coupled bile acid receptor 1
HGNC id	19680

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   GPBAR1 and NR1H4 expression levels are decreased in the aging kidney and caloric restriction prevents these age-related decreases constitutional       gain of function bile acids evoke placental inflammation by activating GPBAR1/NFKB1 pathway in intrahepatic cholestasis of pregnancy constitutional       gain of function bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating GPBAR1

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may serve as an attractive therapeutic tool for cancer immunology inflammatory   may serve as an attractive therapeutic tool for human renal inflammation related diseases diabete     activation of both NR1H4 and GPBAR1 may represent an effective therapy for managing diabetes obesity     activation of both NR1H4 and GPBAR1 may represent an effective therapy for managing obesity digestive liver steatosis activation of both NR1H4 and GPBAR1 may represent an effective therapy for managing hepatic steatosis, obesity, and diabetes miscelleaneous urinary   NR1H4 and GPBAR1 agonists play an important role in preventing progression of kidney disease, atherosclerosis, and vascular calcification

ANIMAL & CELL MODELS

Gpbar1 agonism ameliorates liver histology in a rodent model of steatohepatitis (NASH) and promotes the browning of white adipose tissue