| 1 | GPBAR1
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| TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue.
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| Velazquez-Villegas LA, Perino A, Lemos V, Zietak M, Nomura M, Pols TWH, Schoonjans K.
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| Nat Commun 9(1):245. doi: 10.1038/s41467-017-02068-0.
2018
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| 2 | GPBAR1, NR1H4
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| Bile acid receptors and the kidney.
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| Herman-Edelstein M, Weinstein T, Levi M.
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| Curr Opin Nephrol Hypertens 27(1):56-62. doi: 10.1097/MNH.0000000000000374.
2018
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| 3 | GPBAR1
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| Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.
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| Carino A, Cipriani S, Marchianò S, Biagioli M, Scarpelli P, Zampella A, Monti MC, Fiorucci S.
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| Sci Rep 7(1):13689. doi: 10.1038/s41598-017-13102-y.
2017
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| 4 | GPBAR1
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| The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways.
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| Su J, Zhang Q, Qi H, Wu L, Li Y, Yu D, Huang W, Chen WD, Wang YD.
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| Oncotarget 8(33):54378-54387. doi: 10.18632/oncotarget.17533. eCollection 2017 Aug 15.
2017
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| 5 | GPBAR1, NR1H4
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| A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.
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| Wang XX, Luo Y, Wang D, Adorini L, Pruzanski M, Dobrinskikh E, Levi M.
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| J Biol Chem 292(29):12018-12024. doi: 10.1074/jbc.C117.794982. Epub 2017 Jun 8.
2017
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| 6 | GPBAR1
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| Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.
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| Sasaki T, Mita M, Ikari N, Kuboyama A, Hashimoto S, Kaneko T, Ishiguro M, Shimizu M, Inoue J, Sato R.
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| PLoS One 12(6):e0179226. doi: 10.1371/journal.pone.0179226. eCollection 2017.
2017
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| 7 | GPBAR1, NR1H4
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| Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
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| Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL.
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| J Biol Chem 292(26):11055-11069. doi: 10.1074/jbc.M117.784322. Epub 2017 May 6.
2017
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| 8 | GPBAR1
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| TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-β1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling.
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| Xiong F, Li X, Yang Z, Wang Y, Gong W, Huang J, Chen C, Liu P, Huang H.
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| Endocrine 54(3):657-670. doi: 10.1007/s12020-016-1032-4. Epub 2016 Jul 28.
2016
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| 9 | GPBAR1, NFKB1
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| Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy.
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| Zhang Y, Pan Y, Lin C, Zheng Y, Sun H, Zhang H, Wang J, Yuan M, Duan T, Du Q, Chen J.
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| J Mol Cell Biol 8(6):530-541. Epub 2016 Jul 8.
2016
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| 10 | GPBAR1, NR1H4
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| Role of Bile Acid-Regulated Nuclear Receptor FXR and G Protein-Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease).
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| Levi M.
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| Hypertension 67(6):1080-4. doi: 10.1161/HYPERTENSIONAHA.115.06417. Epub 2016 Apr 4. Review. No abstract available.
2016
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| 11 | GPBAR1
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| Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis.
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| Kumar DP, Asgharpour A, Mirshahi F, Park SH, Liu S, Imai Y, Nadler JL, Grider JR, Murthy KS, Sanyal AJ.
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| J Biol Chem 291(13):6626-40. doi: 10.1074/jbc.M115.699504. Epub 2016 Jan 12.
2016
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| 12 | GPBAR1
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| TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.
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| Reich M, Deutschmann K, Sommerfeld A, Klindt C, Kluge S, Kubitz R, Ullmer C, Knoefel WT, Herebian D, Mayatepek E, Häussinger D, Keitel V.
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| Gut 65(3):487-501. doi: 10.1136/gutjnl-2015-309458. Epub 2015 Sep 29.
2016
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| 13 | GPBAR1
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| TGR5 signaling reduces neuroinflammation during hepatic encephalopathy.
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| McMillin M, Frampton G, Tobin R, Dusio G, Smith J, Shin H, Newell-Rogers K, Grant S, DeMorrow S.
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| J Neurochem 135(3):565-76. doi: 10.1111/jnc.13243. Epub 2015 Sep 10.
2015
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| 14 | GPBAR1
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| The Bile Acid Receptor TGR5 and Liver Regeneration.
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| Jourdainne V, Péan N, Doignon I, Humbert L, Rainteau D, Tordjmann T.
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| Dig Dis 33(3):319-26. doi: 10.1159/000371668. Epub 2015 May 27.
2015
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| 15 | GPBAR1
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| GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.
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| Lou G, Ma X, Fu X, Meng Z, Zhang W, Wang YD, Van Ness C, Yu D, Xu R, Huang W.
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| PLoS One 9(4):e93567. doi: 10.1371/journal.pone.0093567. eCollection 2014.
2014
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| 16 | GPBAR1
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| A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G Protein-coupled receptor (GPCR) TGR5.
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| Spomer L, Gertzen CG, Schmitz B, Häussinger D, Gohlke H, Keitel V.
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| J Biol Chem 289(6):3689-702. doi: 10.1074/jbc.M113.502344. Epub 2013 Dec 13.
2014
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| 17 | GPBAR1
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| Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.
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| Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T.
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| Arterioscler Thromb Vasc Biol 33(7):1663-9. doi: 10.1161/ATVBAHA.113.301565. Epub 2013 Apr 25.
2013
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| 18 | GPBAR1
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| The TGR5 receptor mediates bile acid-induced itch and analgesia.
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| Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU.
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| J Clin Invest 123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.
2013
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| 19 | GPBAR1
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| Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.
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| Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS, Sanyal AJ.
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| Biochem Biophys Res Commun 427(3):600-5. doi: 10.1016/j.bbrc.2012.09.104. Epub 2012 Sep 27.
2012
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| 20 | GPBAR1
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| TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
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| Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K.
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| Cell Metab 14(6):747-57. doi: 10.1016/j.cmet.2011.11.006.
2011
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| 21 | GPBAR1
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| The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
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| Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ.
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| Mol Endocrinol 25(6):1066-71. doi: 10.1210/me.2010-0460. Epub 2011 Mar 31.
2011
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| 22 | GPBAR1
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| The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes.
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| Keitel V, Ullmer C, Häussinger D.
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| Biol Chem 391(7):785-9. doi: 10.1515/BC.2010.077.
2010
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| 23 | GPBAR1
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| TGR5-mediated bile acid sensing controls glucose homeostasis.
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| Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K.
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| Cell Metab 10(3):167-77. doi: 10.1016/j.cmet.2009.08.001.
2009
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| 24 | GPBAR1
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| Expression and function of the bile acid receptor TGR5 in Kupffer cells.
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| Keitel V, Donner M, Winandy S, Kubitz R, Häussinger D.
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| Biochem Biophys Res Commun 372(1):78-84. doi: 10.1016/j.bbrc.2008.04.171. Epub 2008 May 9.
2008
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| 25 | GPBAR1
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| The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.
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| Keitel V, Reinehr R, Gatsios P, Rupprecht C, Gorg B, Selbach O, Haussinger D, Kubitz R.
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| Hepatology 45(3):695-704. 2007
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| 26 | GPBAR1
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| A G protein-coupled receptor responsive to bile acids.
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| Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S,Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M.
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| J Biol Chem 278(11):9435-40. Epub 2003 Jan 10. 2003
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| 27 | GPBAR1
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| Identification of membrane-type receptor for bile acids (M-BAR).
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| Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E,Nakamura T, Itadani H, Tanaka K.
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| Biochem Biophys Res Commun 298(5):714-9. 2002
|