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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

COL25A1

contributors: mct - updated : 31-01-2011

HGNC name	collagen, type XXV, alpha 1
HGNC id	18603

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DURS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         Alzheimer disease

Susceptibility

to Alzheimer disease

Variant & Polymorphism other	genetic evidence of association between COL25A1 and risk for Alzheimer disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer modulation of COL25A1 function may represent an alternative therapeutic intervention for Alzheimer disease neurology neurodegenerative alzheimer useful for future therapeutic interventions aimed at finding compounds that modulate the binding of COL25A1 to APP deposits

ANIMAL & CELL MODELS

Col25a1 knockout mice exhibited loss of motor axon elongation and branching in the muscles, which resulted in axon degeneration