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FLASH GENE

Symbol

CD274

contributors: mct/npt/pgu - updated : 04-05-2018

HGNC name	CD274 molecule
HGNC id	17635

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   on leukemia cells of acute monocyte leukemia, can significantly affect the immunotherapeutic efficacies of the patients and is a novel prognostic marker for acute monocyte leukemia tumoral     --over   overexpression in keratinocytes promotes the epithelial-mesenchymal transition and accelerates carcinogenesis tumoral     --over   of the immune modulatory molecule CD274 in anaplastic meningioma tumoral     --over   in leukemic lymphocytes, higher levels of CD274 than circulating B lymphocytes from normal donors constitutional     --over   in Multiple sclerosis (MS) lesions elevated CD274 expression by glial cells

Susceptibility

to subacute sclerosing panencephalitis (SSPE) to autoimmune Addison disease (AAD) and Graves disease (GD)

Variant & Polymorphism SNP , other	GCG(C) haplotype containing -606G allele significantly higher in SSPE patients than in controls
	SNP showing modest association with both AAD and GD

Candidate gene
Marker	CD274 expression is an independent negative prognostic factor in human breast cancer
Therapy target
	System Type Disorder Pubmed cancer hemopathy   targeting of Cd274 may represent a novel therapeutic approach

ANIMAL & CELL MODELS