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FLASH GENE
Symbol CD274 contributors: mct/npt/pgu - updated : 04-05-2016
HGNC name CD274 molecule
HGNC id 17635
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
on leukemia cells of acute monocyte leukemia, can significantly affect the immunotherapeutic efficacies of the patients and is a novel prognostic marker for acute monocyte leukemia
tumoral     --over  
overexpression in keratinocytes promotes the epithelial-mesenchymal transition and accelerates carcinogenesis
tumoral     --over  
of the immune modulatory molecule CD274 in anaplastic meningioma
tumoral     --over  
in leukemic lymphocytes, higher levels of CD274 than circulating B lymphocytes from normal donors
constitutional     --over  
in Multiple sclerosis (MS) lesions elevated CD274 expression by glial cells
Susceptibility
  • to subacute sclerosing panencephalitis (SSPE)
  • to autoimmune Addison disease (AAD) and Graves disease (GD)
  • Variant & Polymorphism SNP , other
  • GCG(C) haplotype containing -606G allele significantly higher in SSPE patients than in controls
  • SNP showing modest association with both AAD and GD
  • Candidate gene
    Marker
  • CD274 expression is an independent negative prognostic factor in human breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    targeting of Cd274 may represent a novel therapeutic approach
    ANIMAL & CELL MODELS