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| compound Sox2(beta-geo/DeltaENH) heterozygote mice show important cerebral malformations, with parenchymal loss and ventricle enlargement, and L-dopa-rescuable circling behaviour and epilepsy ( | |
absence in Lcc/Lcc mice or reduced expression in YYsb/Ysb mice of the transcription factor SOX2 lead to hearing and balance impairment ( |
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Mice heterozygous for a targeted disruption of Sox2 showed abnormal anterior pituitary development with reduced levels of growth hormone, luteinizing hormone, and thyroid-stimulating hormone ( |
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SOX2-overexpressing cells exhibit cell-cycle arrest and apoptosis and may be related to gastric carcinogenesis and poor prognosis ( |
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knockdown of Sox2 in Human embryonic stem cells results in reduced expression of several key stem cell factors, including Oct4 and Nanog ( |
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SOX2 silencing caused human Müller stem cells to rapidly adopt a neural-like morphology and induced apoptosis, suggesting a crucial role of this factor on human Müller stem cells survival in vitro ( |