Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SOX2 contributors: mct/shn - updated : 01-03-2018
HGNC name SRY (sex determining region Y)-box 2
HGNC id 11195
ANIMAL & CELL MODELS
  • compound Sox2(beta-geo/DeltaENH) heterozygote mice show important cerebral malformations, with parenchymal loss and ventricle enlargement, and L-dopa-rescuable circling behaviour and epilepsy (
  • absence in Lcc/Lcc mice or reduced expression in YYsb/Ysb mice of the transcription factor SOX2 lead to hearing and balance impairment (
  • Mice heterozygous for a targeted disruption of Sox2 showed abnormal anterior pituitary development with reduced levels of growth hormone, luteinizing hormone, and thyroid-stimulating hormone (
  • SOX2-overexpressing cells exhibit cell-cycle arrest and apoptosis and may be related to gastric carcinogenesis and poor prognosis (
  • knockdown of Sox2 in Human embryonic stem cells results in reduced expression of several key stem cell factors, including Oct4 and Nanog (
  • SOX2 silencing caused human Müller stem cells to rapidly adopt a neural-like morphology and induced apoptosis, suggesting a crucial role of this factor on human Müller stem cells survival in vitro (