| protein
| POU2F1, POU5F1 |
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OTX2 (coordinate RAX expression in eye development, providing molecular linkages among the genes responsible for ocular malformation) |
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LHX3 (SOX2 is able to activate transcription of the LHX3 promoter) |
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paired box 6, Pax6 ( |
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Oct1 and Hoxb1 ( |
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binds and activates transcription of the LHX3 proximal promoter in vitro ( |
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beta-catenin as the transcription partner for SOX2 and act in synergy in the transcription regulation of CCND1 in breast cancer cells ( |
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EYA1 |
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ZNF281 directly activate NANOG expression by binding to a site in the promoter in very close proximity to the POU5F1 and SOX2 binding sites |
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SALL1 is expressed in a differentiation-dependent manner and physically interacts with NANOG and SOX2, two components of the core pluripotency network |
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SOX2 and CHD7 physically interact, have overlapping genome-wide binding sites and regulate a set of common target genes including JAG1, GLI3 and MYCN |
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coupled with CHD7 cooperatively regulate target genes that are essential during neural stem cell development |
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connection between SOX2 and BMI1 in maintaining self-renewal and identify BMI1 as a key mediator of SOX2 function |
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involved in the synergistic activation of NANOG, that requires a multisubunit stem cell coactivator complex (SCC) |
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PARP1 regulates SOX2 protein activity (regulation of SOX2 activity by PARP1 is critical for efficient generation of induced pluripotent stem cells) |
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cooperates with POU5F1 to activate downstream target genes by binding to Oct-Sox enhancers |
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SOX2 directly transactivates the ASXL1 promoter, and ASXL1 may be a direct target of SOX2 and may play a role in maintaining the pluripotency of stem cells |
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novel regulatory relationship between the NTRK3 gene and the transcription factor SOX2 |
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OTX2 prevents the presumptive RPE region from forming the neural retina (NR) by repressing the expression of both FGF8 and SOX2 which induce the NR cell fate |
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directly up-regulates the expression of BIRC5, which inhibits the mitochondria-dependent apoptotic pathway in NSCs (neural stem cells) |
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genomic redistribution of POU5F1 by alternative partnering with SOX2 and SOX17 is a fundamental regulatory event of endodermal specification |
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fine balance between SOX2 and CDX2 expression in the gastrointestinal tract is essential for proper development and that ectopic expression of SOX2 may lead to malformations of the gut |
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SIX3 is a SOX2 transcriptional target |
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SOX2 regulated the transcription of PQBP1 in neural stem progenitor cells (NSPCs) |
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direct physical interaction between NANOG and SOX2 regulates embryonic stem cell self-renewal |
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CUL5 interacts extensively with ELOB/ELOC via residues that are highly conserved in CUL2 but not in other cullins, and also interacts with SOCS2, but via only two residues, Pro184 and Arg186, which are located in the C-terminal part of the SOCS box called the CUL5 box |
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IL6 induced the lineage commitment and stemness loss in multipotent cells by decreasing SOX2 expression |
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ACTL6A could interact with NANOG and SOX2 and promote NANOG binding to pluripotency genes such as POU5F1 and SOX2 |
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MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression through direct binding and activation of the NODAL promoter |
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binding between DDX17 and SOX2, although this interaction was largely restricted to reporter responsive (RR) cells |
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NOS1 is transported into the nucleus and interacted with SOX2 to form a NOS1-SOX2 complex in neurons at the early stage following glutamate stimulation |
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NACC1 coordinates differentiation by activating POU5F1 and inhibiting both SOX2 and TCF3 |
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novel roles for PCGF6 in directly regulating POU5F1, NANOG, SOX2, and LIN28A expression to maintain ESC identity |
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SOX2 and LEF1 interact with PITX2 to regulate incisor development and stem cell renewal |
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MELK serves a key role in cancer stem cells (CSCs) through the regulation of SOX2 |
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SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways |
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SOX2-SLC7A11 regulatory axis that confers resistance to ferroptosis in lung cancer stem-like cells |
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ZBTB38 is essential for early embryonic development via the suppression of NANOG and SOX2 expression |
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| compound Sox2(beta-geo/DeltaENH) heterozygote mice show important cerebral malformations, with parenchymal loss and ventricle enlargement, and L-dopa-rescuable circling behaviour and epilepsy ( | |
absence in Lcc/Lcc mice or reduced expression in YYsb/Ysb mice of the transcription factor SOX2 lead to hearing and balance impairment ( |
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Mice heterozygous for a targeted disruption of Sox2 showed abnormal anterior pituitary development with reduced levels of growth hormone, luteinizing hormone, and thyroid-stimulating hormone ( |
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SOX2-overexpressing cells exhibit cell-cycle arrest and apoptosis and may be related to gastric carcinogenesis and poor prognosis ( |
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knockdown of Sox2 in Human embryonic stem cells results in reduced expression of several key stem cell factors, including Oct4 and Nanog ( |
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SOX2 silencing caused human Müller stem cells to rapidly adopt a neural-like morphology and induced apoptosis, suggesting a crucial role of this factor on human Müller stem cells survival in vitro ( |
