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FLASH GENE

Symbol

MTCH2

contributors: mct/shn/pgu - updated : 19-09-2015

HGNC name	mitochondrial carrier homolog 2 (C. elegans)
HGNC id	17587

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p11.2      Physical location : 47.638.858 - 47.664.206
Synonym name	Met-induced mitochondrial protein
	mitochondrial carrier homolog 2
	mitochondrial carrier 2
Synonym symbol(s)	2310034D24Rik, HSPC032, MIMP, SLC25A50

DNA

TYPE	functioning gene
STRUCTURE	25.35 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D11S1344 - D11S4109 - MTCH2 - D11S4117 - D11S1784 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014342 13 - 2628 NP_055157 33 303 - 2005 15899861

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Nervous brain       moderately Reproductive female system ovary     moderately   female system uterus     lowly   male system       highly Respiratory lung       lowly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose white     Homo sapiens Muscular smooth     lowly Muscular striatum skeletal   lowly

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six transmembrane domains
	an energy transfer signature motif

HOMOLOGY

interspecies	ortholog to MTCH2, Pan troglodytes
	ortholog to Mtch2, Mus musculus
	ortholog to Mtch2, Rattus norvegicus
	ortholog to mtch2, Danio rerio

Homologene

FAMILY

mitochondrial carrier family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus
text	a surface-exposed outer mitochondrial membrane protein

basic FUNCTION	mitochondrial target of truncated BID and this MTCH2-resident complex participates in the mitochondrial apoptotic program
	mitochondrial carrier homologue upregulated by Met-hepatocyte growth factor (HGF) signal transduction, which leads to mitochondrial depolarization
	a critical role in liver apoptosis by regulating the recruitment of tBID to mitochondria
	has a major role in the mitochondrial outer membrane permeabilization by facilitating the recruitment of truncated BID protein to mitochondria
	may play a role in cellular processes underlying obesity

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	complexing with truncated BID
	interaction of MTCH2 and tBID is a potential target for therapeutic control of BID initiated cell death
	binding of BID to MTCH2 suggesting both a quasi-constitutive residence of BID in MTCH2-bound state in healthy cells and its CASP8-mediated cleavage there under apoptotic conditions
	role for MOAP1 in FAS signaling in the liver by promoting MTCH2-mediated BID recruitment to mitochondria

cell & other

REGULATION

induced by

Met-hepatocytes growth factor/scatter factor (HGF/SF)

Other

up-regulated in NIH-3T3 cells

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism	associated with body mass index

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of truncated BID protein to mitochondria, the activation of Bax/Bak, mitochondrial outer membrane permeabilization and apoptosis
	MTCH2/MIMP conditional knockout in liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria