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FLASH GENE

Symbol

PLD3

contributors: mct - updated : 11-04-2022

HGNC name	phospholipase D3
HGNC id	17158

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCA46

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in Alzheimer disease (AD) brains, which was negatively correlated with amyloid precursor protein (APP) and amyloid-beta (Abeta) levels constitutional     --low   in the human hippocampus in AD cases compared to controls

Susceptibility

to Alzheimer's disease (AD)

Variant & Polymorphism other	coding variant confers increased risk for the development of Alzheimer's disease (AD)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer targeting PLD3 may provide new opportunities for AD therapeutic strategies

ANIMAL & CELL MODELS